Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation
A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.
Jung, Hoi-Yun,Chang, Sukbok,Hong, Sungwoo
supporting information
p. 7099 - 7103
(2019/09/07)
Ruthenium-catalyzed para-selective oxidative cross-coupling of arenes and cycloalkanes
A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.
Guo, Xiangyu,Li, Chao-Jun
supporting information; experimental part
p. 4977 - 4979
(2011/11/12)
Pincer thioamide and pincer thioimide palladium complexes catalyze highly efficient negishi coupling of primary and secondary alkyl zinc reagents at room temperature
Pincer thioamide PdII complex 2 was prepared, and its reaction with cyclohexylzinc chloride yielded novel pincer thioimide PdII complex 3 besides Pd0 species. The structures of complexes 2 and 3 were confirmed by X-ray ana
SYNTHESIS OF POLYCARBOXYLIC ACIDS OF BIPHENYL. II. OXIDATION OF CYCLOHEXYLTOLUENES AND METHYLBIPHENYLS TO CARBOXYLIC ACIDS
During the liquid-phase catalytic oxidation of cyclohexyltoluenes and methylbiphenyls in the presence of a cobalt catalyst the methyl group exhibits high reactivity, and it increases in the series of ortho, meta, and para isomers. The minimal reactivity of the methyl group at the ortho position is explained by steric factors.
Koshel', S. G.,Shutova, I. V.,Shapiro, Yu. E.,Obukhova, T. A.,Rusakov, A. I.,Koshel', G. N.
p. 292 - 295
(2007/10/02)
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