- Catalytic asymmetric bromine-lithium exchange: A new tool to build axial chirality
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We present here the first catalytic desymmetrization of the 2,2′,6,6′-tetrabromobiphenyl 1 and analogues, by a bromine-lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).
- Perron, Quentin,Alexakis, Alexandre
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supporting information; experimental part
p. 2611 - 2620
(2011/01/05)
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