Fluorescent labeling of specific protein targets in vitro and in vivo
New methods are provided for the post-genomic era that will permit the analysis of the dynamic expression and localization of gene products in living cells. Herein we propose the development of such a method from a bioorganic approach involving organic sy
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(2008/06/13)
Synthesis and characterization of dimaleimide fluorogens designed for specific labeling of proteins
A series of aromatic compounds were prepared bearing two maleimide groups attached directly to the fluorescent cores. The resulting derivatives do not fluoresce until the maleimide groups undergo their typical thiol addition reaction, thus removing their
Girouard, Stephane,Houle, Marie-Helene,Grandbois, Alain,Keillor, Jeffrey W.,Michnick, Stephen W.
p. 559 - 566
(2007/10/03)
Synthesis and in vitro cytotoxicity of aminocoumarin platinum(II) complexes
A number of cis-dichloro[bis(aminocoumarin)platinum(II) complexes have been synthesized and evaluated for their in vitro cytotoxicity against Caco-2T cells. The complex with 7-amino-4-trifluoromethylcoumarin as ligand has been found to be the most active (IC50 10 μ/ml) in this study.
Kokotos, George,Theodorou, Vassiliki,Tzougraki, Chryssa,Deforce, Dieter L.D.,Van Den Eeckhout, Elfreide G.
p. 2165 - 2168
(2007/10/03)
Synthesis and study of substituted coumarins. A facile preparation of D,L-o-tyrosine
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Kokotos,Tzougraki
p. 87 - 92
(2007/10/02)
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