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CAS

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97145-43-2

KKI 5, with the molecular formula C14H18N2O3S, is a synthetic chemical that functions as a potent and selective inhibitor of autophagy. This cellular process is responsible for the degradation and recycling of unnecessary or dysfunctional cellular components. By targeting ULK1, a key protein in the initiation of autophagy, KKI 5 has been instrumental in research aimed at understanding the role of autophagy in biological processes and its potential as a therapeutic target for diseases like cancer and neurodegenerative disorders. Furthermore, KKI 5 holds promise for drug development and the study of cellular homeostasis.

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  • 97145-43-2 Structure

  • Basic information

    1. Product Name: KKI 5
    2. Synonyms: L-glutamamide, 1-acetyl-L-prolyl-L-phenylalanyl-N~5~-(diaminomethylene)-L-ornithyl-L-seryl-L-valyl-
    3. CAS NO:97145-43-2
    4. Molecular Formula: C35H55N11O9
    5. Molecular Weight: 773.888
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 97145-43-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 1.44g/cm3
    6. Refractive Index: 1.651
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 12.94±0.46(Predicted)
    10. Water Solubility: Soluble in water at 1mg/ml
    11. CAS DataBase Reference: KKI 5(CAS DataBase Reference)
    12. NIST Chemistry Reference: KKI 5(97145-43-2)
    13. EPA Substance Registry System: KKI 5(97145-43-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 97145-43-2(Hazardous Substances Data)

97145-43-2 Usage

Uses

Used in Pharmaceutical Research:
KKI 5 is used as a research tool for investigating the role of autophagy in various biological processes. Its ability to inhibit autophagy by targeting ULK1 aids in understanding the implications of this cellular process in health and disease.
Used in Cancer Therapy Development:
In the field of oncology, KKI 5 is used as a potential therapeutic agent for cancer treatment. Its inhibition of autophagy can help in starving cancer cells of their nutrient recycling mechanism, thereby hindering tumor growth and progression.
Used in Neurodegenerative Disorder Research:
KKI 5 is utilized in the study of neurodegenerative disorders to explore the connection between autophagy and the development or progression of such conditions. This can lead to the discovery of novel treatment strategies for diseases like Alzheimer's, Parkinson's, and Huntington's.
Used in Drug Development:
KKI 5 serves as a starting point for the development of new drugs targeting autophagy-related pathways. Its selectivity and potency make it a valuable compound in the creation of medications for a variety of diseases.
Used in Cellular Homeostasis Studies:
In the field of cell biology, KKI 5 is used as a means to study cellular homeostasis. By inhibiting autophagy, researchers can gain insights into how cells maintain balance and respond to stress or damage.

Check Digit Verification of cas no

The CAS Registry Mumber 97145-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,1,4 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 97145-43:
(7*9)+(6*7)+(5*1)+(4*4)+(3*5)+(2*4)+(1*3)=152
152 % 10 = 2
So 97145-43-2 is a valid CAS Registry Number.
InChI:InChI=1/C35H55N11O9/c1-19(2)28(34(55)41-22(29(37)50)13-14-27(36)49)45-32(53)25(18-47)44-30(51)23(11-7-15-40-35(38)39)42-31(52)24(17-21-9-5-4-6-10-21)43-33(54)26-12-8-16-46(26)20(3)48/h4-6,9-10,19,22-26,28,47H,7-8,11-18H2,1-3H3,(H2,36,49)(H2,37,50)(H,41,55)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H4,38,39,40)/t22-,23-,24-,25-,26-,28-/m0/s1

97145-43-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name KALLIKREIN INHIBITOR

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:97145-43-2 SDS

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