- Method for converting furan ammonium salt cis-trans isomer
-
The invention belongs to the technical field of medical intermediate preparation, and specifically relates to a method for converting a furan ammonium salt cis-trans isomer. The method comprises the following steps: dissolving a furan trans isomer (E)-SMIA in an organic solvent, then performing an isomerization reaction with a catalyst in the organic solvent to convert the (E)-SMIA into a cis isomer of furan ammonium salt (Z)-SMIA. In an implementation process of the technology provided by the invention, the catalyst can be recycled; experiments prove that after the catalyst is recycled for 101 times, the product conversion rate is not reduced, and any change of the catalyst structure is not observed; the operation process is simple, no additives are added during the conversion, the generation of other three wastes is avoided, and the production technology is green and environmentally friendly.
- -
-
Paragraph 0035-0150
(2019/01/15)
-
