- Synthesis and Hypoglycemic Activity of N-Alkylated Hydrazonopropionic Acids
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A series of N-alkylated 2-hydrazonopropionic acids have been synthesized and evaluated for their hypoglycemic activity.Most of the compounds exhibit a remarkable blood glucose lowering activity in fasted guinea pigs.Some of the structural variables studie
- Wolff, Hans Peter,Kuehnle, Hans F.
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p. 1436 - 1440
(2007/10/02)
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- Hypoglycaemically active 2-alkyl- or -alkenyl-hydrazono propionic acid derivatives
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A 2-hydrazonopropionic acid derivative of the formula STR1 wherein R is an aliphatic hydrocarbon radical, and X is a valency bond or a divalent aliphatic hydrocarbon radical containing up to 4 carbon atoms, with the proviso that when X is a valency bond, R cannot be saturated cycloalkyl, or a physiologically compatible salt, lower alkyl ester or amide thereof, which exhibit hypoglycaemic activity.
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