97683-31-3 Usage
Uses
Used in Pharmaceutical Industry:
Azuloxa is used as an anti-ulcer agent for the treatment of gastric ulcers and gastritis. It promotes healing of ulcers and, at higher doses, mucosal regeneration in animal models of gastric ulcers induced with cortisone or acetic acid.
Used in Combination Therapy:
Azuloxa is used in combination with anti-ulcer drugs and gastric acid secretion inhibitors to treat digestive tract diseases. In one clinical trial, the combination of Azuloxa sodium and cimetidine administered to patients with unhealing gastric ulcers produced an appreciable rate of healing without any adverse events.
Originator
Kotobuki Seiyaku (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 97683-31-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,6,8 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 97683-31:
(7*9)+(6*7)+(5*6)+(4*8)+(3*3)+(2*3)+(1*1)=183
183 % 10 = 3
So 97683-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H18O3S.Na/c1-4-11-9-15(19(16,17)18)14-8-12(10(2)3)6-5-7-13(11)14;/h5-10H,4H2,1-3H3,(H,16,17,18);/q;+1/p-1
97683-31-3Relevant articles and documents
A ring expansion-annulation strategy for the synthesis of substituted azulenes. Preparation and suzuki coupling reactions of 1-azulenyl triflates
John L Jr., Kane,Shea, Kevin M.,Crombie, Aimee L.,Danheiser, Rick L.
, p. 1081 - 1084 (2007/10/03)
(matrix presented) A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of β′-bromo-α-diazo ketones with rhodium carboxylates The key transformation involves intramolecular addition of a rhodium carbenoid to an arene π-bond, electrocyclic ring opening, β-elimination, tautomerization, and trapping to produce 1-hydroxyazulene derivatives. The synthetic utility of the method is enhanced by the ability of the triflate derivatives to participate in Suzuki coupling reactions, as illustrated in a synthesis of the antiulcer drug egualen sodium (KT1-32).
