- Preparation method of phenyl (3-methoxy-1,2,4-thiadiazole-5-amino) formate
-
The invention discloses a preparation method of phenyl (3-methoxy-1,2,4-thiadiazole-5-amino) formate, and belongs to the field of synthesis of medical intermediates. The preparation method comprises the following steps: starting from O-methyl iso-urea hydrochloride (1), carrying out chlorination reaction to obtain an intermediate (2); carrying out cyclization on the intermediate (2) and thiocyanate in the presence of an ytterbium catalyst to obtain an intermediate (3), and finally reacting the intermediate (3) with phenolate in the presence of CDI to obtain phenyl (3-methoxy-1,2,4-thiadiazole-5-amino) formate. The method is simple, convenient and stable to operate, high in yield and environment-friendly, products in all steps are easy to separate, and a new synthesis way is provided for the compounds.
- -
-
Paragraph 0037; 0040-0041; 0058; 0060-0061
(2021/03/11)
-
- PREPARATION METHOD FOR AND INTERMEDIATE OF PYRROLO SIX-MEMBERED HETEROAROMATIC RING DERIVATIVE
-
Disclosed are an intermediate of a pyrrolo six-membered heteroaromatic ring derivative as a JAK inhibitor and a preparation method therefor, and a method for preparing a pyrrolo six-membered heteroaromatic ring derivative using the intermediate. The metho
- -
-
Paragraph 0119-0121
(2019/10/23)
-
- PREPARATION METHOD FOR PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE AND INTERMEDIATE THEREOF
-
The present invention relates to preparation method for pyrrole six-membered heteroaryl ring derivative and intermediate thereof. Specifically, the present invention relates to a preparation method for pyrrole six-membered heteroaryl ring derivative, inte
- -
-
Page/Page column 27-29
(2019/03/26)
-
- Process for scavenging thiols
-
Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H+/K+-ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.
- -
-
-
