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98049-69-5

LIPOXIN B4, also known as 5(S),14(R)-Lipoxin B4, is a positional isomer of Lipoxin A4 (LXA4) and belongs to the family of anti-inflammatory lipid mediators. It plays a crucial role in signaling the resolution of inflammation and possesses potent inhibitory effects on leukotriene-triggered polymorphonuclear neutrophil (PMN)-endothelial cell interactions and PMN migration.
Used in Pharmaceutical Industry:
LIPOXIN B4 is used as an anti-inflammatory agent for its ability to inhibit leukotriene-induced PMN migration and adhesion, contributing to the resolution of inflammation. Its concentration of 10^-7 M effectively suppresses PMN migration stimulated by leukotriene B4 (LTB4), with an IC50 value of approximately 3 x 10^-10 M.

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  • 6,8,10,12-Eicosatetraenoicacid, 5,14,15-trihydroxy-, (5S,6E,8Z,10E,12E,14R,15S)-

    Cas No: 98049-69-5

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  • Biomol GmbH
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  • 98049-69-5 Structure

  • Basic information

    1. Product Name: LIPOXIN B4
    2. Synonyms: 5(S), 14(R), 15(S)-TRIHYDROXYEICOSA-6E,8Z,10E,12E-TETRAENOIC ACID;LIPOXIN B4;(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-trihydroxyicosa-6,8,10,12-tetraenoic acid;(5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxy-6,8,10,12-icosatetraenoic acid;LXB4;5(S),14(R)-Lipoxin B4;(5S,14R,15S)-5,14,15-Trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoic acid;UXVRTOKOJOMENI-WLPVFMORSA-N
    3. CAS NO:98049-69-5
    4. Molecular Formula: C20H32O5
    5. Molecular Weight: 352.47
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 98049-69-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 589.4 °C at 760 mmHg
    3. Flash Point: 324.3 °C
    4. Appearance: Clear oil dissolved in ethanol
    5. Density: 1.096 g/cm3
    6. Vapor Pressure: 2.39E-16mmHg at 25°C
    7. Refractive Index: 1.54
    8. Storage Temp.: -20°C
    9. Solubility: N/A
    10. CAS DataBase Reference: LIPOXIN B4(CAS DataBase Reference)
    11. NIST Chemistry Reference: LIPOXIN B4(98049-69-5)
    12. EPA Substance Registry System: LIPOXIN B4(98049-69-5)

  • Safety Data

    1. Hazard Codes: F,Xi
    2. Statements: 11-36/37/38
    3. Safety Statements: 16-26-36
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 98049-69-5(Hazardous Substances Data)

98049-69-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 98049-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,4 and 9 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 98049-69:
(7*9)+(6*8)+(5*0)+(4*4)+(3*9)+(2*6)+(1*9)=175
175 % 10 = 5
So 98049-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-8-14-18(22)19(23)15-10-7-5-4-6-9-12-17(21)13-11-16-20(24)25/h4-7,9-10,12,15,17-19,21-23H,2-3,8,11,13-14,16H2,1H3,(H,24,25)/b6-4-,7-5+,12-9+,15-10+/t17-,18+,19-/m1/s1

98049-69-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name LIPOXIN B4

1.2 Other means of identification

Product number -
Other names 5(S),14(R)-Lipoxin B4

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98049-69-5 SDS

98049-69-5Downstream Products

98049-69-5Relevant articles and documents

SYNTHESIS OF 5S-HYDROXY-14,15 LTA4 A BIOGENIC PRECURSOR TO THE LIPOXINS

Leblanc, Yves,Fitzsimmons, Brian J.,Rokach, Joshua

, p. 3449 - 3452 (2007/10/02)

A synthesis of 5S-hydroxy-14,15-LTA4 10 an intermediate in the biosynthesis of the lipoxins is described.

Stereocontrolled Total Synthesis of Lipoxins B

Nicolaou, K. C.,Webber, S. E.

, p. 453 - 461 (2007/10/02)

A stereocontrolled total synthesis of six lipoxin B isomers are described.The flexible and stereoselective strategy involves Sharpless asymmetric epoxidation and pinylborane asymmetric reduction to secure the three hydroxyl-bearing stereocenters and a Wittig-type as well as palladium(0)-copper(I) coupling reactions to construct the carbon skeleton of the target molecules.

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