- Synthesis of benzoxazines, quinazolines and 4H-benzo[e][1,3]thiazine by ANRORC rearrangements of 1,2,4-oxadiazoles
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1,2,4-Oxadiazoles undergo ANRORC (addition of nucleophile, ring-opening and ring-closure) rearrangements upon reaction with excess of n-butyllithium to give benzoxazines, benzothiazines, and quinazolines in good yields under mild conditions. Georg Thieme Verlag Stuttgart · New York.
- Draghici, Bogdan,El-Gendy, Bahaa El-Dien M.,Katritzky, Alan R.
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supporting information; experimental part
p. 547 - 550
(2012/04/04)
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- Synthesis and Antibacterial Activity of 2,2'-Dithiobis(benzamide) Derivatives against Mycobacterium Species
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A series of compounds, which are analogues of 2,2'-dithiobis(benzamide), were synthesized and tested for in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv including resistant strains against streptomycin, kanamycin, or isonicotinic acid hydrazide.MICs of these compounds against a typical mycobacteria, Mycobacterium kansasii and Mycobacteruim intracellulare were also examined.Structure-activity relationships were found in a series of (acyloxy)alkyl ester derivatives depending upon the length of alkyl carbon chain.The MIC of the most potent compound , 2,2'-dithiobisbenzamide> was superior or at least equivalent to streptomycin, kanamycin, and ethanbutol.All the compounds showed no cross-resistance between the current antitubercular agents.
- Okachi, Ryo,Niino, Hideki,Kitaura, Kozo,Mineura, Kazuyuki,Nakamizo, Yoshinobu,et al.
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p. 1772 - 1779
(2007/10/02)
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