- Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi
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Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on
- Amaral, Maiara,Romanelli, Maiara M.,Tempone, Andre G.,Varela, Marina T.,de Castro Levatti, Erica V.,Fernandes, Jo?o Paulo S.
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- SUBTANCES FOR THE PROTECTION OF CELLS AND/OR TISSUES
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The invention relates to substances that are suitable for protecting cells and/or tissues.
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(2010/06/14)
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- Derivative of dihydroxybenzamide and a pharmaceutical composition having an anti-inflammatory activity
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Disclosed herein are a derivative of dihydroxybenzamide represented by the formula(I): STR1 wherein (1) R1 represents a hydrogen atom or a lower alkyl group and R2 represents a straight chain-alkyl group of 4 to 12 carbon atoms, a branched chain-alkyl group of 4 to 12 carbon atoms, a cyclo-alkyl group of 4 to 12 carbon atoms, STR2 wherein n is an integer of 1 to 6, or a pyridyl group which is substituted or unsubstituted, or (2) R1 and R2 are cyclized to make a heterocycle containing amino group represented by the formula STR3 wherein X represents a nitrogen atom or a methine and Y represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms or a phenyl group, and a pharmaceutical composition containing the same.
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