- Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
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In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical trials with uricosurics have demonstrated that
- B-Rao, Chandrika,Kulkarni-Almeida, Asha,Katkar, Kamlesh V.,Khanna, Smriti,Ghosh, Usha,Keche, Ashish,Shah, Pranay,Srivastava, Ankita,Korde, Vaidehi,Nemmani, Kumar V.S.,Deshmukh, Nitin J.,Dixit, Amol,Brahma, Manoja K.,Bahirat, Umakant,Doshi, Lalit,Sharma, Rajiv,Sivaramakrishnan
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experimental part
p. 2930 - 2939
(2012/06/29)
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- NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
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The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
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Page/Page column 194
(2008/06/13)
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