Synthesis and Antimetastatic Properties of Stereoisomeric Tricyclic Bis(dioxopiperazine) Analogues in a B16 Melanoma Model
The synthesis for trans and cis tricyclic bis(dioxopiperazine)s 5 and 6 from pyrazine-2,3-dicarboxamide (7) is described.Stereoselective antimetastatic activity differences for these analogues were observed following pretreatment of B16-F10 melanoma cells in vitro.Activities for these isomers were compared with selected intermediates, and the data are discussed in relation to previous results obtained with cis- and trans-cyclopropane analogues.
Witiak, Donald T.,Trivedi, Bharat K.,Campolito, Laura B.,Zwilling, Bruce S.,Reiches, Nancy A.
p. 1329 - 1332
(2007/10/02)
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