Design, synthesis and antimicrobial evaluation of methyl pyridyl-2,4-dioxobutanoates and Some new derived ring systems
This work describes the synthesis of new series of compounds derived from methyl pyridyl-2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties in order to investigate their preliminary in vitro antibacteria
Elzahhara, Perihan A.S.,Solimana, Raafat,El-Hawash, Soad A.M.,Ragaba, Hanan M.A.,Youssefa, Amal M.,Wahab, Abeer E. Abdel
p. 407 - 414
(2017/01/06)
Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase
α,γ-Diketo acids (DKA) were discovered from screening as selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. The diketo acid moiety proved essential for activity, while substitution on the γ position was necessary for selectivity and potency. Optimization led to the identification of a DKA inhibitor of NS5b polymerase with IC50 = 45 nM, one of the most potent HCV NS5b polymerase inhibitors reported.
Summa, Vincenzo,Petrocchi, Alessia,Pace, Paola,Matassa, Victor G.,De Francesco, Raffaele,Altamura, Sergio,Tomei, Licia,Koch, Uwe,Neuner, Philippe
p. 14 - 17
(2007/10/03)
More Articles about upstream products of 98589-58-3