Regiospecific Opening of Oxetanes with Trimethylsilyl Cyanide - Zinc Iodide. A General Approach to γ-Amino Alcohols.
Trimethylsilyl ethers of γ-hydroxy isonitriles were formed regiospecifically in the opening of oxetanes with trimethylsilyl cyanide - zinc iodide.Deprotection and hydrolysis of the initially formed ring cleavage products gave γ-amino alcohols.