Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility
A novel series of water-soluble derivatives of limonin were synthesized by introducing various tertiary amines onto the C (7)-position of limonin. Ten target compounds were characterized and screened for their anti-inflammatory and analgesic activity in v
Limonin as a Starting Point for the Construction of Compounds with High Scaffold Diversity
Structurally complex natural products have been a fruitful source for the discovery and development of new drugs. In an effort to construct a compound collection populated by architecturally complex members with unique scaffolds, we have used the natural
Furiassi, Lucia,Hergenrother, Paul J.,Tonogai, Emily J.
supporting information
p. 16119 - 16128
(2021/06/14)
Limonoid A cyclic aminolysis derivatives, and the preparation method and medical application thereof
The invention belongs to the field of medicinal chemistry, and specifically relates to limonoid A cyclic ammonolysis derivatives I and II, a preparation method thereof, and pharmaceutical compositionscontaining the compounds. Pharmacodynamic tests prove that the compounds disclosed by the invention have application of treating inflammation and pain. (Formulae are shown in the description.).
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Paragraph 0089; 0091-0092
(2018/05/30)
Limonin - 7 - amino derivatives, its manufacturing method and medical use
The invention relates to the field of pharmaceutical chemistry and particularly relates to water-soluble limonin-7-amino derivatives (I) and (II) shown in the specification, and a preparation method and medicine application thereof. Pharmacological experiments prove that the compounds disclosed by the invention have the analgesic and anti-inflammatory effects and can be clinically used for relieving pain and inflammatory diseases.