- Cu nanorods and nanospheres and their excellent catalytic activity in chemoselective reduction of nitrobenzenes
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Highly selective chemical route for the hydrothermal synthesis of Cu0 nanorods and nanospheres using a long chain saturated fatty acid, viz. lauric acid as template is reported. Our experimental results revealed Cu nanorods are of ca. 14 nm diameters and 100-235 nm length, whereas the nanospheres are of dimensions 2-15 nm diameter. Cu nanospheres show much enhanced catalytic activity over the nanorods for the chemoselective reduction of 4-nitrophenol and 5-nitroisophthalic acid to respective substituted anilines in one pot at room temperature, suggesting the role of particle size and shape in catalytic reduction.
- Patra, Astam Kumar,Dutta, Arghya,Bhaumik, Asim
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- Structural diversity and luminescent sensing of three coordination polymers based on the hydrolysates of N,N′-bis(3,5-dicarboxylatophenyl)pyromelliticdi-imide)
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Based on the hydrolysates of N,N′-bis(3,5-dicarboxylatophenyl)pyromelliticdi-imide) (H4L) and 1,3-bis(imidazol-1-ylmethyl)benzene (bimb), three coordination polymers, namely, {[Zn(BTC)0.5(bimb)]·4H2O}n (1), [Cu(BTC)0.5(bimb)]n (2), and {[Cd(AIP)(H2O)]·H2O}n (3), have been obtained under solvothermal conditions. The possible hydrolysis mechanism of H4L was investigated here. Structural analyses reveal that complex 1 is a 3D (4,4)-c {64.82}{66}2-bbf net. Complex 2 displays a 2D 4-c {32.62.72}-kgm sheet. While complex 3 exhibits a 3D (3,6)-c {4.62}2{42.610.83}-rtl net based on binuclear {Cd2(COO)4} SBUs. Besides, luminescent sensing investigation indicated that 1 and 3 exhibit highly sensitive and selective sensing of chromate anions in aqueous solution.
- Fan, Liming,Wang, Jiang,Zhao, Li,Zhang, Yujuan,Wang, Xiaoqing,Hu, Tuoping,Zhang, Xiutang
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- Method for preparing 5-aminoisophthalic acid
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The invention creatively provides a method for preparing high-purity 5-aminoisophthalic acid. The method is characterized in that 5-nitroisophthalic acid is used as the raw material, and nitryl is reduced through hydrazine hydrate/ raney nickel under the alkali condition; then the product is acidized with acetic acid until the pH is 3.5-4.0, and thus the high-purity 5-aminoisophthalic acid can be separated out. Compared with a currently publically reported preparation method, the preparation method has the advantages that the nitryl is reduced through hydrazine hydrate/raney nickel; the acetic acid is utilized for acidizing to separate out the product; the side reaction is few; the yield is high; the product purity is 99.5% or above; the operation is simple and convenient; the industrial production can be carried out.
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Paragraph 0020; 0021; 0022; 0023; 0024; 0025
(2017/07/19)
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- Naaladase inhibitors for treating retinal disorders and glaucoma
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The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
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- Naaladase inhibitors for treating amyotrophic lateral sclerosis
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The present invention relates to pharmaceutical compositions and methods for treating amyotrophic lateral sclerosis using NAALADase inhibitors.
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- Benzenedicarboxylic acid derivatives
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New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
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- PROCESS FOR THE PREPARATION OF A HALOSUBSTITUTED AROMATIC ACID
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The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid, comprising the following steps: a) catalytic hydrogenation of 5-nitro-1,3-benzenedicarboxylic acid in neutral or basic environment, which gives an aqueous solution of 5-amino-1,3-benzenedicarboxylic acid sodium salt; b) direct iodination of the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution deriving from step a), without further purification, with a solution of ICl in HCl, being the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution previously added with HCl and H2SO4.
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- PROCESS FOR THE PREPARATION OF A DICARBOXYLIC ACID DICHLORIDE
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The present invention refers to a Process for the preparation of S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride of formula (I) comprising the reaction between S-(-)-[2-(acetyloxy)]propionic acid chloride and 5-amino-2,4,6-triiodo-, 1,3-benzenedicarboxylic acid dichloride, in an aprotic dipolar solvent and in presence of a halogenhydric acid.
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- Synthesis of achiral linker reagents for direct labelling of oligonucleotides on solid supports
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Full experimental procedures for the synthesis of a series of new functional linker reagents (14-16) and solid supports (11-13) are reported. The achiral linker reagents and supports can be used for high yield incorporation of free amino groups, fluorescein or biotin into DNA oligomers.
- Behrens, Carsten,Dahl, Otto
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p. 291 - 305
(2007/10/03)
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- Process for the preparation of a dicarboxylic acid di-chloride
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The present invention refers to a Process for the preparation of S-(-)-5-??2-(acetyloxy)-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride of formula (I) comprising the reaction between S-(-)-?2-(acetyloxy)!propionic acid chloride and 5-amino-2,4,6-triiodo-, 1,3-benzenedicarboxylic acid dichloride, in an aprotic dipolar solvent and in presence of a halogenhydric acid.
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- Disazo dyestuffs
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Disazo dyestuffs have been found which, in the form of the free acid, correspond to the formula (I) STR1 represents H or an optionally substituted aliphatic or aromatic radical and R1 to R6 and A have the meaning given in the description, which are outstandingly suitable for inkjet printing.
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- Selective hydrogenolysis of bis(hydroxymethyl)aromatic compounds
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Selective hydrogenolysis of symmetric bis(hydroxymethyl)aromatic compounds has been performed over Raney nickel in alkaline solution for 24-36 h at 20°C. The yield of the corresponding monohydrogenolysis product was in the range of 75-96%. The usefulness of the reaction was demonstrated by the synthesis of 4-(bromomethyl)benzoic acid.
- Behrens,Egholm,Buchardt
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p. 1235 - 1236
(2007/10/02)
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- Fiber-reactive disazo brown dye having vinylsulfone-type reactive group
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A compound, or a salt thereof, represented by the following formula, STR1 wherein A is a substituted or unsubstituted phenylene or naphthylene group, B is STR2 in which R3 is a hydrogen atom or a lower alkyl, lower alkoxy, acylamino or ureido group, and R4 is a hydrogen atom or a lower alkyl or lower alkoxy group, R1 and R3 are independently a hydrogen atom or a substituted or unsubstituted lower alkyl group, X is a substituted or unsubstituted amino, lower alkoxy, substituted phenoxy or sulfo group, Y is --SO2 CH=CH2 or --SO2 CH2 CH2 Z, in which Z is a group capable of being split by the action of an alkali, and m is 2 or 3, which is useful for dyeing hydroxyl group- or amide group-containing fiber materials to give dyed products of a brown color having excellent fastness properties with good build-up property.
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