cas 990-73-8, Fentanyl citrate | Articles data

Articles about 990-73-8Total 2 be found

An efficient, optimized synthesis of fentanyl and related analogs
The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.
Valdez, Carlos A.,Leif, Roald N.,Mayer, Brian P.
(2015/02/19)

SUBSTITUTED 4-AMINO-PIPERIDINES
The present invention relates to new substituted 4-amino-piperidine opioid receptor modulators, pharmaceutical compositions thereof, and methods of use thereof
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Page/Page column 20

(2010/02/17)

Chemical Properties

Appearance/Colour :White powder
Melting Point: 153-156 °C
Boiling Point: 466.2 °C at 760 mmHg
Flash Point:185.8 °C
Solubility:Soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent).
Storage Temp.:2-8°C
PSA: 155.68000
LogP: 2.82610

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