Synthesis of 6,7-ethylenedioxyquinoxalines and pyrido[2,3-b]pyrazines as intermediates in the preparation of antineoplastic agents
A convenient procedure for the synthesis of quinoxalines and pyridopyrazines has been developed from aryldiamines. The condensation of aminocarbamates such as 12 with ethyl 2,3-dibromopropionate provide the quinoxaline 14 directly, in a one-step operation. The methodology reported herein represents an alternative to condensation of o-phenylenediamines with α-dicarbonyl compounds for the quinoxalines formation. The same procedure was applied to the 2,3-diaminopyridine to obtain the corresponding pyridopyrazines.
Mateu,Capilla,Harrak,Pujol
p. 5241 - 5250
(2007/10/03)
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