New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase
We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.
Fonvielle, Matthieu,Therisod, Helene,Hemery, Marion,Therisod, Michel
p. 410 - 413
(2007/10/03)
Role of base catalysts upon the Pudovik reaction: Unexpected synthesis of 1,2-dihydropyridine phosphonate derivatives
The role of base catalysts (CsNaX zeolite, hydrotalcite, triethylamine and pyridine derivatives) upon the regioselectivity of the Pudovik reaction is studied. The unexpected synthesis of stable 1,2-dihydropyridine phosphonate derivatives via a one-pot addition reaction under mild conditions is described.
Albouy, Dominique,Lasperas, Monique,Etemad-Moghadam, Guita,Koenig, Max