Synthesis of 4-amino-2(5H)-furanones through intra- and intermolecular nitrile addition of ester enolates. Construction of carbon framework of an antitumor antibiotic basidalin
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Hiyama,Oishi,Suetsugu,et al.
p. 2139 - 2150
(2007/10/02)
NEW SYNTHETIC METHODS FOR 4-AMINO-2(5H)-FURANONES
Two new efficient methods are disclosed for the synthesis of the title compounds: (1) base-promoted ring closure of 2-acyloxy alkanenitrile and (2) acid-mediated lactonization of t-butyl-4-alkoxy-3-amino-2-alkenoates.