- Pyrrolidinone derivatives, their preparation and pharmaceutical composition comprising the same
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The present invention relates to substituted pyrrolidinone compounds of formula 1, wherein n is 0 or 1; Aza is a heterocycle optionally substituted with C1-4 alkyl, or C1-4 alkyl substituted with a heterocycle, which represents a saturated or unsaturated five- or six-membered ring having nitrogen(s) as a heteroatom, which are muscarinic acetylcholine receptor agonists and useful as nootropics and therapeutic agents for cerebral neural diseases such as Alzheimer's disease; and pharmaceutically acceptable salts thereof; processes for the preparation thereof; and pharmaceutical compositions comprising these compounds or salts.
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- Synthesis of 1'-Methylspiro from 1-Methyl-n-piperidinecarbaldehydes
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1'-Methylspiro 2 can be obtained from 1-methyl-n-piperidinecarbaldehydes 1 by the Fischer reaction of their phenylhydrazones.The Fischer reaction provides different kinds of products -3H-indole, indole and oxindole- which depend on the N atom position in the piperidine ring.
- Benito, Y.,Canoira, L.,Martinez-Lopez, N.,Rodriguez, J. G.,Temprano, F.
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p. 623 - 628
(2007/10/02)
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- Hydroformylation of Nitrogen-Containing Cyclic Olefins via "in-situ" Rhodium-Phosphine Catalysts
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Hydroformylation of nitrogen-containing cyclic olefins (N-substituted nortropidines, N-methyl-1,2,3,6-tetrahydropyridine (THP)) with rhodium-PR3 catalysts prepared "in-situ" is reported.The nortropidines reacted rapidly when either trialkyl- or triaryl-type phosphines were used, and the regioselectivities were not significantly influenced by the nature of the phosphine.With the less basic THP the rates and selectivities were generally lower, and were influenced by the phosphine ligand and by the presence of added bases such as Et3N.
- Prokai-Tatrai, K.,Toeroes, S.,Heil, B.
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p. 231 - 236
(2007/10/02)
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