- Process for preparing α-L-aspartyl-L-phenylalanine methyl ester
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A process for preparing α-L-aspartyl-L-phenylalanine methyl ester: STR1 in which: (a) the compound methyl N(α-L-aspartyl)α-aminocinnamate, protected at the nitrogen, of formula: STR2 where R is a protector group at the nitrogen, is subjected to hydrogenation at the olefin bond by means of gaseous hydrogen in the presence of a hydrogenation catalyst, to give the compound of formula: STR3 where R has the aforesaid meaning, in the form of a mixture of α-L-aspartyl-L-phenylalanine methyl ester protected at the nitrogen, and α-L-aspartyl-D-phenylalanine methyl ester protected at the nitrogen; (b) the protector group is removed from the α-L-aspartyl-L-phenylalanine and α-L-aspartyl-D-phenylalanine methyl esters protected at the nitrogen; (c) the α-L-aspartyl-L-phenylalanine methyl ester is separated and recovered from the deprotection reaction product.
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