- Copper(II) complexes of diamino diamide and diamino diamine in aqueous solution
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In order to study the difference on the equilibrium, spectral properties of copper(II) complexes of diamino diamide and diamino diamine, new tetradentate ligands, 4,7-dimethyl-4,7-diazadecanediamide (4,7-N,N′ -Me2-L-2,2,2) and 1,10-diamino-4,7-
- Chao, Min-Shiun,Huang, Shih-Liang
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- Prodrug derivatives of enzyme inhibitors having hydroxyl groups, a process for preparing them, and their use
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The invention concerns prodrugs of enzyme inhibitors in which at least one OH-- group in the enzyme inhibitor has been converted into a derivative grouping of the formula III, IV or V: STR1 in which the groups R11 to R25 and s,l, m, o, q, and r are as defined in the description. Such prodrugs exhibit an improved solubility in water and improved pharmaco-kinetic characteristics.
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