100-20-9Relevant articles and documents
Incorporating Pendent Fullerenes with High Refractive Index Backbones: A Conjunction Effect Method for High Refractive Index Polymers
Chen, Shuang,Chen, Dongxue,Lu, Min,Zhang, Xin,Li, He,Zhang, Xiaoyan,Yang, Xiaoming,Li, Xiaohong,Tu, Yingfeng,Li, Christopher Y.
, p. 8480 - 8488 (2015)
To achieve high refractive index polymers (HRIPs), we report here the design and synthesis of four fullerene polyesters (P1-P4), based on the conjunction effect from the high refractive index polyester backbones and pendent fullerene side chains. At sodiu
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Nakano et al.
, p. 808 (1977)
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Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels
Robinson, Ken,Easton, Christopher J.,Dulhunty, Angela F.,Casarotto, Marco G.
, p. 1957 - 1971 (2018)
Ryanodine receptor (RyR) Ca2+-release channels are essential for contraction in skeletal and cardiac muscle and are prime targets for modification of contraction in disorders that affect either the skeletal or heart musculature. We designed and synthesized a number of compounds with structures based on a naturally occurring peptide (A peptides) that modifies the activity of RyRs. In total, 34 compounds belonging to eight different classes were prepared. The compounds were screened for their ability to enhance Ca2+ release from isolated cardiac sarcoplasmic reticulum (SR) vesicles, with 25 displaying enhanced Ca2+ release. Competition studies with the parent peptides indicated that the synthetic compounds act at a competing site. The activity of the most effective of the compounds, BIT 180, was further explored using Ca2+ release from skeletal SR vesicles and contraction in intact skeletal muscle fibers. The compounds did not alter tension in intact fibers, indicating that (as expected) they are not membrane permeable, but importantly, that they are not toxic to the intact cells. Proof in principal that the compounds would be effective in intact muscle fibers if rendered membrane permeable was obtained with a structurally related membrane-permeable scorpion toxin (imperatoxin A), which was found to enhance contraction.
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Rabjohn
, p. 5479,5481 (1954)
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Effect of regioisomerism on the self-assembly and photophysical behavior of 1,3,4-thiadiazole-based polycatenars
Pathak, Suraj Kumar,Nath, Subrata,Gupta, Ravindra Kumar,Rao, D. S. Shankar,Prasad, S. Krishna,Achalkumar, Ammathnadu S.
, p. 8166 - 8182 (2015)
A new class of polycatenars, where the central benzene ring is connected to two arms derived from substituted 1,3,4-thiadiazoles at the 1,3- and 1,4-positions, was synthesized and characterized. These thiadiazole-based molecules are promising as they stabilize columnar phases over a wide temperature range, in comparison to their oxadiazole analogues. The para-substituted polycatenars exhibited a columnar hexagonal and/or a columnar oblique phase, while the meta-substituted polycatenars exhibited solely a columnar oblique phase. The para-substituted polycatenars exhibited green emission, while the meta-substituted polycatenars exhibited blue emission in solution and film states. Stabilization of a broad range columnar phase and luminescence in the solid state make these new compounds promising from the viewpoint of applications in emissive displays. The self-assembly and luminescence of these regioisomers was greatly influenced by the molecular structure.
Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses
Liang, Fengying,Eda, Kazuo,Okazoe, Takashi,Wada, Akihiro,Mori, Nobuaki,Konishi, Katsuhiko,Tsuda, Akihiko
, p. 6504 - 6517 (2021)
The Vilsmeier reagent (VR), first reported a century ago, is a versatile reagent in a variety of organic reactions. It is used extensively in formylation reactions. However, the synthesis of VR generally requires highly toxic and corrosive reagents such as POCl3, SOCl2, or COCl2. In this study, we found that VR is readily obtained from a CHCl3 solution containing N,N-dimethylformamide or N,N-dimethylacetamide upon photo-irradiation under O2 bubbling. The corresponding Vilsmeier reagents were obtained in high yields with the generation of gaseous HCl and CO2 as byproducts to allow their isolations as crystalline solid products amenable to analysis by X-ray crystallography. With the advantage of using CHCl3, which bifunctionally serves as a reactant and a solvent, this photo-on-demand VR synthesis is available for one-pot syntheses of aldehydes, acid chlorides, formates, ketones, esters, and amides.
Synthesis and characteriation of novel poly (ester amide)s containing benzthiazole heterocyclic ring
Patel,Desai,Patel
, p. 203 - 208 (2004)
The novel Poly (ester-amide)s (PEAs) were prepared by inrter-facial polycondensation of 5 - hydroxy - 2 - amino benzthiazole with various di-basic acid chlorides. The PEAs were characterized by elements analysis, IR spectra studies, Mn estimated by non aqueous conductometric titration and thermogravimetry. The electric conductivity of all the poly (ester amide)s PEAs was also measured at room temperature and it was found that the PEAs have semiconducting properties.
Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist
Kassack, Matthias U.,Braun, Kirsten,Ganso, Matthias,Ullmann, Heiko,Nickel, Peter,Boeing, Barbara,Mueller, Gregor,Lambrecht, Guenter
, p. 345 - 357 (2004)
NF449 [4,4′,4″,4′′′-(carbonylbis(imino-5,1,3- benzenetriyl-bis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid-octasodiumsalt)] was recently described to inhibit recombinant rP2X 1 receptors (Naunyn Schmiedeberg's Arch. Pharmacol. 364 (2001
Photolysis of p-Phenylbis(chlorodiazirine), Studied by Matrix Isolation Spectroscopy. Generation, Detection and Characterization of p-Phenylenebis(chloromethylene)
Tomioka, Hideo,Komatsu, Kazunori,Nakayama, Takehito,Shimizu, Masayoshi
, p. 1291 - 1294 (1993)
Photolysis of the title bis-diazirine matrix-isolated in Ar at 10 K monitored by IR and UV/vis spectroscopy indicated that the diazirine underwent stepwise elimination of N2 to produce 3-(4-chlorocarbenophenyl)-3-chlorodiazirine which then eliminated the
Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids
Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna
supporting information, p. 685 - 689 (2021/04/09)
The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.
BENZENE 1,4-BIS(BISPHOSPHONIC ACID)-BASED METAL COMPLEXES, METHOD OF SYNTHESIS AND APPLICATIONS THEREOF
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Paragraph 0103; 0104, (2021/10/15)
The invention provides extended bisphosphonate-based metal complexes using benzene1,4-bis(bisphosphonic acid) (BBPA), an analog of benzene 1,4-dicarboxylic acid (BDC). Hydrothermal synthesis of BBPA with the bioactive metals Ca2+, Zn2+/su
