100-38-9Relevant articles and documents
Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
Hao, Jing,Kos, Petra,Zhou, Kejin,Miller, Jason B.,Xue, Lian,Yan, Yunfeng,Xiong, Hu,Elkassih, Sussana,Siegwart, Daniel J.
, p. 9206 - 9209 (2015)
The ability to control chemical functionality is an exciting feature of modern polymer science that enables precise design of drug delivery systems. Ring-opening polymerization of functional monomers has emerged as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functional groups have been introduced into lactones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained elusive. We report a strategy that enabled the rapid synthesis of >130 lipocationic polyesters directly from functional monomers without protecting groups. These polymers are highly effective for siRNA delivery at low doses in vitro and in vivo.
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Fukuto,Stafford
, p. 6083 (1957)
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Preparation method of aliphatic mercaptan
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Paragraph 0030; 0032-0035; 0037-0039; 0041-0042; 0044; ..., (2021/08/28)
The invention provides a novel method for preparing (CH3CH2) 2NCH2CH2SH, i.e., the reaction is carried out at a lower temperature, and the reaction is controllable by adopting a manner of dropwise adding materials, so that the safe production is realized.
A diethylamino thiol preparation method
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0029, (2017/08/25)
The invention relates to a preparation method for diethylaminoethanethiol. The preparation method comprises firstly putting ethylene sulfide in a sealed reactor, slowly stirring, adding ethene diamine, heating to 30 DEG C-40 DEG C, dropwise adding a sodiu