100-38-9

Basic information

• Product Name: 2-Diethylaminoethanethiol
• Synonyms: n,n-diethyl-cysteamine;N-Diaethyl cysteamin;n-diaethylcysteamin;n-diethylcysteamine;Triethylamine, 2-mercapto-;DIETHYLAMINOETHANE THIOL;DIETHYLAMINOETHANETHIOL(2-);2-(DIETHYLAMINO)ETHANETHIOL
• CAS NO: 100-38-9
• Molecular Formula: C₆H₁₅NS
• Molecular Weight: 133.26
• EINECS: 202-846-8
• Mol File: 100-38-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 161.588 °C at 760 mmHg
• Flash Point: 51.527 °C
• Appearance: /
• Density: 0.899 (estimate)
• Vapor Pressure: 2.26mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• PKA: 8.89±0.10(Predicted)
• CAS DataBase Reference: 2-Diethylaminoethanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Diethylaminoethanethiol(100-38-9)
• EPA Substance Registry System: 2-Diethylaminoethanethiol(100-38-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 100-38-9(Hazardous Substances Data)

Usage

Chemical Properties

Colourless to Pale Orange Oil

Uses

2-(Diethylamino)ethanethiol is an intermediate in the synthesis of (S)-Pregabalin (P704790).

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 950, 1948 DOI: 10.1021/ja01183a018

InChI:InChI=1/C6H15NS/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3

Upstream product

• 21770-86-5 O-ethyl S-(2-diethylamino)ethyl methylphosphonothiolate 
• 1942-52-5 2-(diethylamino)ethanethiol hydrochloride 
• 7647-01-0 hydrogenchloride 
• 14441-55-5 diethylaminoethylthio benzoate 
• 64-17-5 ethanol 
• 78-53-5 O,O-diethyl S-(2-diethylaminoethyl) thiophosphate 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 100-37-8 2-(Diethylamino)ethanol 
• 5978-05-2 Butylcarbamidsaeure-<2-mercapto-aethylester> 
• 109-89-7 diethylamine 
• 5842-22-8 thiocarbonic acid O-ethyl ester-S-(2-hydroxy-ethyl ester) 
• 93029-88-0 Dithiokohlensaeure-S-<2-diethylamino-ethylester>-S-methylester 
• 3326-89-4 [1,3]oxathiolan-2-one 
• 55847-36-4 2-chloroethane thioacetate 

Downstream Products

• 63868-77-9 N-[3-(2-diethylamino-ethylmercapto)-propyl]-phthalimide 
• 7708-55-6 benzyl 2-(diethylamino)ethyl sulfide 
• 131252-76-1 (2,6-dimethyl-phenyl)-thiocarbamic acid S-(2-diethylamino-ethyl ester) 
• 82-99-5 diphenyl-thioacetic acid S-(2-diethylamino-ethyl ester) 
• 4358-87-6 (RS)-methyl mandelate 
• 96116-65-3 diethyl-(2-cyclohexylmercapto-ethyl)-amine 
• 101428-02-8 mesityl-thiocarbamic acid S-(2-diethylamino-ethyl ester) 
• 101265-99-0 2-hydroxy-4-nitro-thiobenzoic acid S-(2-diethylamino-ethyl ester) 
• 23713-11-3 dithiophosphoric acid O,O'-diethyl ester-S-(2-diethylamino-ethyl ester) 
• 195195-29-0 2,7-bis-(2-diethylamino-ethylmercapto)-4-methyl-[1,8]naphthyridine 
• 102288-64-2 Cyclohexyl-phenyl-thioessigsaeure-S-(2-diethylamino-ethylester) 
• 56225-19-5 {2-[5-(2-Diethylamino-ethylsulfanyl)-2,4-dinitro-phenylsulfanyl]-ethyl}-diethyl-amine 

Relevant articles and documents

Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery

The ability to control chemical functionality is an exciting feature of modern polymer science that enables precise design of drug delivery systems. Ring-opening polymerization of functional monomers has emerged as a versatile method to prepare clinically translatable degradable polyesters.1 A variety of functional groups have been introduced into lactones; however, the direct polymerization of tertiary amine functionalized cyclic esters has remained elusive. We report a strategy that enabled the rapid synthesis of >130 lipocationic polyesters directly from functional monomers without protecting groups. These polymers are highly effective for siRNA delivery at low doses in vitro and in vivo.

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Preparation method of aliphatic mercaptan

The invention provides a novel method for preparing (CH3CH2) 2NCH2CH2SH, i.e., the reaction is carried out at a lower temperature, and the reaction is controllable by adopting a manner of dropwise adding materials, so that the safe production is realized.

A diethylamino thiol preparation method

The invention relates to a preparation method for diethylaminoethanethiol. The preparation method comprises firstly putting ethylene sulfide in a sealed reactor, slowly stirring, adding ethene diamine, heating to 30 DEG C-40 DEG C, dropwise adding a sodiu