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1000025-07-9

1000025-07-9

Identification

  • Product Name:Vadadustat

  • CAS Number: 1000025-07-9

  • EINECS:

  • Molecular Weight:306.705

  • Molecular Formula: C14H11ClN2O4

  • HS Code:

  • Mol File:1000025-07-9.mol

Synonyms:Vadadustat

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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  • Manufacture/Brand:TRC
  • Product Description:Vadadustat
  • Packaging:5mg
  • Price:$ 195
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  • Product Description:Vadadustat >98%
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  • Product Description:Vadadustat >98%
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  • Manufacture/Brand:Crysdot
  • Product Description:Vadadustat(AKB-6548/PG-1016548) 97%
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  • Manufacture/Brand:Crysdot
  • Product Description:Vadadustat(AKB-6548/PG-1016548) 97%
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  • Manufacture/Brand:Crysdot
  • Product Description:Vadadustat(AKB-6548/PG-1016548) 97%
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  • Manufacture/Brand:ChemScene
  • Product Description:Vadadustat 99.25%
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  • Manufacture/Brand:ChemScene
  • Product Description:Vadadustat 99.25%
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  • Product Description:Vadadustat 99.25%
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  • Product Description:Vadadustat 99.25%
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Relevant articles and documentsAll total 14 Articles be found

MANUFACTURING PROCESS FOR 3,5-DICHLOROPICOLINONITRILE FOR SYNTHESIS OF VADADUSTAT

-

, (2022/01/12)

Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the syn

Preparation method of valduxostat and intermediate thereof

-

Paragraph 0067-0076, (2021/09/15)

The invention relates to a preparation method of valduxostat and an intermediate thereof, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: taking 3-chloro-5-(3-chlorphenyl)-2-cyanopyridine as a starting material, carrying out hydrolysis reaction, and then carrying out condensation reaction to obtain a compound, namely the intermediate; and further reacting the intermediate compound to obtain vadadustat. The method has the advantages of short route, simple and easily available raw materials, low cost and mild reaction conditions, and is suitable for industrial large-scale production.

Preparation method of pyridine cyclic compound

-

, (2020/06/16)

The invention provides a preparation method of a pyridine cyclic compound, and belongs to the field of pharmaceutical chemicals. The method comprises the steps: mixing 3,5-dihydroxypicolinic acid, concentrated sulfuric acid and an alcohol solvent, and performing esterification reaction to obtain 3,5-dihydroxypicolinic acid methyl ester; then sequentially carrying out protection group feeding and ammoniation to obtain {[5-(3-chlorphenyl)-3-hydroxypyridin-2-yl]amino}acetic acid. The product produced by the method has the characteristics of high purity, high yield, low cost, simple operation andstable process.

Process route upstream and downstream products

Process route

2-Cyano-3,5-dichloropyridine
85331-33-5

2-Cyano-3,5-dichloropyridine

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 25.5 h / 50 °C / Inert atmosphere
2.1: methanol / 24 h / Reflux; Inert atmosphere
3.1: hydrogenchloride; water / 42 h / 102 - 104 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / 2 h / 3 - 20 °C / Inert atmosphere
4.2: 16 h / 10 - 20 °C
5.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C
5.2: pH 1
With hydrogenchloride; methanol; water; pivaloyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 18 h / 45 °C / Inert atmosphere
2: methanol / 20 h / Reflux; Inert atmosphere
3: hydrogen bromide / water / 20 h / Reflux
4: 1,1'-carbonyldiimidazole; N-ethyl-N,N-diisopropylamine
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In methanol; water; N,N-dimethyl-formamide;
Multi-step reaction with 5 steps
1.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 25 h / 50 °C / Inert atmosphere
2.1: sodium methylate / 24 h / Inert atmosphere; Reflux
3.1: hydrogenchloride / water / 42 h / 102 - 104 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
4.2: 0 - 20 °C
5.1: water; potassium hydroxide / 2-methyltetrahydrofuran / 20 °C
With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;
Multi-step reaction with 5 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 4 h / 45 °C / Inert atmosphere; Large scale
2.1: methanol / 6 h / Reflux; Inert atmosphere; Large scale
3.1: sodium hydroxide; water / methanol / 6 h / Reflux
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
4.2: 1 h / 20 °C
5.1: aluminum (III) chloride / N,N-dimethyl acetamide / 6 h / 85 °C
With aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
2-Cyano-3,5-dichloropyridine
85331-33-5

2-Cyano-3,5-dichloropyridine

methyl [5-(3-chlorophenyl)-3-hydroxy-2-pyridinecarboxamido]acetate

methyl [5-(3-chlorophenyl)-3-hydroxy-2-pyridinecarboxamido]acetate

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 4 h / 45 °C / Inert atmosphere; Large scale
2.1: methanol / 6 h / Reflux; Inert atmosphere; Large scale
3.1: sodium hydroxide; water / methanol / 6 h / Reflux
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
4.2: 1 h / 20 °C
5.1: aluminum (III) chloride / N,N-dimethyl acetamide / 14 h / 85 °C
With aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
N-[5-(3-chlorophenyl)-3-methoxypyridine-2-carbonyl]glycine

N-[5-(3-chlorophenyl)-3-methoxypyridine-2-carbonyl]glycine

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
With hydrogen bromide; at 95 ℃; for 28h; Green chemistry;
98.9%
With hydrogenchloride; acetic acid; In water; at 100 ℃; for 24h;
94.4%
methyl 2-(5-(3-chlorophenyl)-3-methoxypicolinamido)acetate

methyl 2-(5-(3-chlorophenyl)-3-methoxypicolinamido)acetate

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
methyl 2-(5-(3-chlorophenyl)-3-methoxypicolinamido)acetate; With aluminium trichloride; In N,N-dimethyl-formamide; at 85 ℃;
With water; pyrographite; sodium hydroxide; In acetone; at 60 ℃; for 1h; Solvent; Temperature; Reagent/catalyst;
85.2%
With aluminum (III) chloride; In N,N-dimethyl acetamide; at 85 ℃; for 6h; Temperature; Time;
84%
5-(3-chlorophenyl)-3-hydroxy-picolinic acid methyl ester

5-(3-chlorophenyl)-3-hydroxy-picolinic acid methyl ester

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
With sodium ethanolate; In methanol; at 75 ℃; Reagent/catalyst; Inert atmosphere;
90.2%
With sodium ethanolate; In ethanol; at 75 ℃; Inert atmosphere;
88.3%
5-(3-chlorophenyl)-2-(N-glycine methylester carboxylic amide)-3-(2,2-dimethyl-1-oxopropoxy) pyridine

5-(3-chlorophenyl)-2-(N-glycine methylester carboxylic amide)-3-(2,2-dimethyl-1-oxopropoxy) pyridine

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
With water; potassium hydroxide; In 2-methyltetrahydrofuran; at 20 ℃;
90%
methyl [5-(3-chlorophenyl)-3-hydroxy-2-pyridinecarboxamido]acetate

methyl [5-(3-chlorophenyl)-3-hydroxy-2-pyridinecarboxamido]acetate

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
With water; potassium hydroxide; In 2-methyltetrahydrofuran; at 20 - 30 ℃; for 3h; Inert atmosphere;
100%
With water; sodium hydroxide; In tetrahydrofuran; at 30 ℃;
93.17%
{[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
With hydrogenchloride; In tetrahydrofuran; water; pH=1; Product distribution / selectivity;
88%
{[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h;
With hydrogenchloride; In tetrahydrofuran; water;
64%
methyl 3-chloro-5-(3-chlorophenyl)pyridine-2-carboxylate

methyl 3-chloro-5-(3-chlorophenyl)pyridine-2-carboxylate

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
With sodium methylate; In methanol; at 20 ℃; for 26h;
61.8%
3-chlorophenylboronic acid
63503-60-6

3-chlorophenylboronic acid

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 25.5 h / 50 °C / Inert atmosphere
2.1: methanol / 24 h / Reflux; Inert atmosphere
3.1: hydrogenchloride; water / 42 h / 102 - 104 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / 2 h / 3 - 20 °C / Inert atmosphere
4.2: 16 h / 10 - 20 °C
5.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C
5.2: pH 1
With hydrogenchloride; methanol; water; pivaloyl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 18 h / 45 °C / Inert atmosphere
2: methanol / 20 h / Reflux; Inert atmosphere
3: hydrogen bromide / water / 20 h / Reflux
4: 1,1'-carbonyldiimidazole; N-ethyl-N,N-diisopropylamine
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In methanol; water; N,N-dimethyl-formamide;
Multi-step reaction with 5 steps
1.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 25 h / 50 °C / Inert atmosphere
2.1: sodium methylate / 24 h / Inert atmosphere; Reflux
3.1: hydrogenchloride / water / 42 h / 102 - 104 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
4.2: 0 - 20 °C
5.1: water; potassium hydroxide / 2-methyltetrahydrofuran / 20 °C
With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide;
Multi-step reaction with 5 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide; water / 4 h / 45 °C / Inert atmosphere; Large scale
2.1: methanol / 6 h / Reflux; Inert atmosphere; Large scale
3.1: sodium hydroxide; water / methanol / 6 h / Reflux
4.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
4.2: 1 h / 20 °C
5.1: aluminum (III) chloride / N,N-dimethyl acetamide / 6 h / 85 °C
With aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
Multi-step reaction with 5 steps
1.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 25 h / 50 °C
2.1: methanol / 24 h / Reflux
3.1: hydrogenchloride / water / 42 h / 102 - 104 °C
4.1: 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 1 h / 45 °C
4.2: 2.5 h / 20 °C
5.1: sodium hydroxide; tetrahydrofuran / tetrahydrofuran / 2 h / 20 °C
With tetrahydrofuran; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
Multi-step reaction with 6 steps
1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 25 h / 50 °C
2: methanol / 24 h / Reflux
3: hydrogenchloride / water / 42 h / 102 - 104 °C
4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
6: potassium hydroxide / water; 2-methyltetrahydrofuran / 20 °C
With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine
1415226-39-9

5-(3-chlorophenyl)-3-methoxy-2-cyanopyridine

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid
1000025-07-9

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / 42 h / 102 - 104 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / 2 h / 3 - 20 °C / Inert atmosphere
2.2: 16 h / 10 - 20 °C
3.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C
3.2: pH 1
With hydrogenchloride; water; pivaloyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran;
Multi-step reaction with 2 steps
1: hydrogen bromide / water / 20 h / Reflux
2: 1,1'-carbonyldiimidazole; N-ethyl-N,N-diisopropylamine
With hydrogen bromide; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In water;
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 42 h / 102 - 104 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
2.2: 0 - 20 °C
3.1: water; potassium hydroxide / 2-methyltetrahydrofuran / 20 °C
With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; water;
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water / 4 h / 100 °C
2.1: 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 1 h / 45 °C
2.2: 3 h / 30 °C
3.1: hydrogenchloride; acetic acid / water / 24 h / 100 °C
With hydrogenchloride; acetic acid; 1,1'-carbonyldiimidazole; sodium hydroxide; In water; dimethyl sulfoxide;
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / methanol / 6 h / Reflux
2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
2.2: 1 h / 20 °C
3.1: aluminum (III) chloride / N,N-dimethyl acetamide / 6 h / 85 °C
With aluminum (III) chloride; water; 1,1'-carbonyldiimidazole; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl acetamide;
Multi-step reaction with 3 steps
1.1: hydrogenchloride / water / 42 h / 102 - 104 °C
2.1: 1,1'-carbonyldiimidazole / dimethyl sulfoxide / 1 h / 45 °C
2.2: 2.5 h / 20 °C
3.1: sodium hydroxide; tetrahydrofuran / tetrahydrofuran / 2 h / 20 °C
With tetrahydrofuran; hydrogenchloride; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide;
Multi-step reaction with 4 steps
1: hydrogenchloride / water / 42 h / 102 - 104 °C
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C
4: potassium hydroxide / water; 2-methyltetrahydrofuran / 20 °C
With hydrogenchloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; water;

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