100019-40-7

Basic information

• Product Name: 4-hydroxy-2,2-dimethyl-2,3,4,6-tetrahydro-5H-pyrano[3,2-c]quinolin-5-one
• CAS NO: 100019-40-7
• Molecular Formula: C₁₄H₁₅NO₃
• Molecular Weight: 245.2738
• Mol File: 100019-40-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 475.3°C at 760 mmHg
• Flash Point: 241.3°C
• Density: 1.31g/cm³
• Vapor Pressure: 7.66E-10mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 4-hydroxy-2,2-dimethyl-2,3,4,6-tetrahydro-5H-pyrano[3,2-c]quinolin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2,2-dimethyl-2,3,4,6-tetrahydro-5H-pyrano[3,2-c]quinolin-5-one(100019-40-7)
• EPA Substance Registry System: 4-hydroxy-2,2-dimethyl-2,3,4,6-tetrahydro-5H-pyrano[3,2-c]quinolin-5-one(100019-40-7)

Safety Data

• Hazardous Substances Data: 100019-40-7(Hazardous Substances Data)

Upstream product

• 91794-23-9 4-keto-2,2-dimethyl-3,4,5,6-tetrahydro-2H-pyrano<3,2-c>quinolin-5-one 
• 103-72-0 phenyl isothiocyanate 
• 135299-36-4 4-hydroxy-3-(3-methylbutanoyl)-2-methylmercapto quinoline 
• 135299-37-5 4-chloro-3-(3-methylbutanoyl)-2-methylmercaptoquinoline 
• 135299-38-6 4-chloro-3-(3-methyl-2-butenoyl)-2-methylmercapto quinoline 
• 135299-39-7 2-isopropyl-4-methylmercapto-3(2H)-oxofuro<3,2-e>quinoline 
• 135299-35-3 ethyl 3-keto-5-methyl-2-hexanoate 
• 108-10-1 4-methyl-2-pentanone 

Downstream Products

• 523-64-8 flindersine 
• 6391-66-8 3,4-dihydro-2,2-dimethyl-2H,5H-pyrano<3,2-c>quinolin-5-one 

Relevant articles and documents

A new synthesis of flindersine

Ketene S,N-acetal from the carbethoxylated isobutyl methyl ketone undergoes thermal cyclization with N-phenyl to give 4-hydroxy-3-(3-methylbutanoyl)-2-thiomethylquinoline (III) which is transformed into the corresponding 4-chloro derivative (IV).The carbonyl group in the side chain at 3-position of VI is converted into the α,β-unsaturated ketone (V) followed by acid hydrolysis to afford 4-keto-2,2-dimethyl-3,4,5,6-tetrahydro-2H-pyranoquinolin-5-one (VI).Reduction of 4-keto group of VI and subsequent dehydration of the resulting alcohol furnishes flindersine (I).