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10002-97-8

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10002-97-8 Usage

General Description

(3alpha,5beta,17beta)-estrane-3,17-diol, also known as 3β,5β,17β-androstan-3α-ol-17-one, is a steroid and a metabolite of testosterone. It is a compound found in the body and is known to be involved in various physiological processes, including the regulation of reproductive function and sexual characteristics. This chemical is also used in the pharmaceutical industry for the synthesis of various hormones and as a reference standard in analytical chemistry. Additionally, it has been studied for its potential role in the treatment of hormone-related disorders such as menopause and andropause. Overall, (3alpha,5beta,17beta)-estrane-3,17-diol plays an important role in the endocrine system and has various applications in medicine and research.

Check Digit Verification of cas no

The CAS Registry Mumber 10002-97-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,0,0 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10002-97:
(7*1)+(6*0)+(5*0)+(4*0)+(3*2)+(2*9)+(1*7)=38
38 % 10 = 8
So 10002-97-8 is a valid CAS Registry Number.

10002-97-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,5R,8R,9R,10S,13S,14S,17S)-13-methyl-1,2,3,4,5,6,7,8,9,10,11,12,14,15,16,17-hexadecahydrocyclopenta[a]phenanthrene-3,17-diol

1.2 Other means of identification

Product number -
Other names UNII-X4SO0472HB

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10002-97-8 SDS

10002-97-8Relevant articles and documents

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Marker,Rohrmann

, p. 2927 (1938)

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Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors

Han, Mingcheng,Zorumski, Charles F.,Covey, Douglas F.

, p. 4218 - 4232 (2007/10/03)

A series of analogues of the neuroactive steroids 3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one were studied to elucidate the mode of binding of 5α- and 5β-reduced steroids to steroid binding sites on GABA(A) receptors. Analogues which were either 3α-hydroxy-20-ketosteroids or 3α-hydroxysteroid-17β-carbonitriles and which contained various methyl group substitution patterns at C-5 and C-10 were prepared. Evaluations utilized whole-cell patch clamp electrophysiological methods carried out on cultured rat hippocampal neurons, and the results obtained with the rigid 17β-carbonitrile analogs were analyzed using molecular modeling methods. The molecular modeling results provide a rationale for the observation that the configuration of the hydroxyl group at C-3 is a greater determinant of anesthetic potency than the configuration of the A,B ring fusion at C-5. The electrophysiological results identify steric restrictions for the space that can be occupied in 5α- and 5β-reduced steriod modulators of GABA(A) recepters in the regions of space proximate to the steroid C-5, C-10, and possibly C-4 positions. This information is useful for the development of nonsteroidal analogues that can modulate GABA(A) receptors via interactions at steroid binding sites.

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