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100020-81-3

100020-81-3

Identification

Synonyms:β-chloro-β-phenylalanine methyl ester hydrochloride

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Safety information and MSDS view more

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  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 2 Articles be found

ON THE SYNTHESIS OF β-PHENYLALANINE

Portelli, Mario

, p. 215 - 216 (2007/10/02)

A practical, economical and efficient two-step synthesis of β-phenylalanine and its methyl ester is reported: ?-phenylserine, 1, is chlorinated to β-chloro-β-phenylalanine, 2; the latter is hydrogenated in the presence of 10percent Pd/C catalyst to give the desired amino acid. β-Phenylalanine is separated (yield based upon β-phenylserine) as the free amino acid 3 (65.3percent yield) or as the hydrochloride 4 (79.8percent yield) or esterified to the methyl ester hydrochloride 5 (78.7percent yield).

Process route upstream and downstream products

Process route

β-hydroxyphenylalanine methyl ester hydrochloride
80182-99-6

β-hydroxyphenylalanine methyl ester hydrochloride

β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

Conditions
Conditions Yield
With thionyl chloride; In chloroform; for 12h; Ambient temperature;
85%
benzaldehyde
100-52-7

benzaldehyde

β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 74.8 percent / NaOH / methanol; H2O / 1.) 16 dg C, 30 min; 2.) RT, overnight
2: SOCl2 / 4 h
3: SOCl2 / 10 h / Heating
With sodium hydroxide; thionyl chloride; In methanol; water;
β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

Conditions
Conditions Yield
With phosphorus pentachloride; acetyl chloride;
Phenylserin
69-96-5

Phenylserin

β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SOCl2 / 4 h
2: SOCl2 / 10 h / Heating
With thionyl chloride;
methanol
67-56-1

methanol

β-chloro-β-phenylalanine
229485-67-0

β-chloro-β-phenylalanine

β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

Conditions
Conditions Yield
With thionyl chloride; for 10h; Yield given; Heating;
β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

methyl 2-amino-3-phenylpropanoate hydrochloride
5619-07-8

methyl 2-amino-3-phenylpropanoate hydrochloride

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol; for 6h; Ambient temperature;
87%
β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

N-benzyloxycarbonyl-L-aspartic acid anhydride
4515-23-5

N-benzyloxycarbonyl-L-aspartic acid anhydride

(S)-3-Benzyloxycarbonylamino-N-(2-chloro-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid

(S)-3-Benzyloxycarbonylamino-N-(2-chloro-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid

Conditions
Conditions Yield
With sodium carbonate; acetic acid; Multistep reaction; 1.) H2O, 23 deg C, 10 min, 2.) ethyl acetate, 0 deg C, 2 h;
n-formylaspartic anhydride
33605-73-1

n-formylaspartic anhydride

β-chloro-β-phenylalanine methyl ester hydrochloride
100020-81-3

β-chloro-β-phenylalanine methyl ester hydrochloride

N-(N-formyl-α-L-aspartyl)-D,L-2-chlorophenylalanine methyl ester
99792-96-8

N-(N-formyl-α-L-aspartyl)-D,L-2-chlorophenylalanine methyl ester

(R)-N-(2-Chloro-1-methoxycarbonyl-2-phenyl-ethyl)-2-formylamino-succinamic acid

(R)-N-(2-Chloro-1-methoxycarbonyl-2-phenyl-ethyl)-2-formylamino-succinamic acid

Conditions
Conditions Yield
With sodium carbonate; acetic acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) H2O, 23 deg C, 10 min, 2.) ethyl acetate, 0 deg C, 2 h;

Global suppliers and manufacturers

Global( 1) Suppliers
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  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:33
  • Country:China (Mainland)
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