1000279-69-5

Basic information

• Product Name: A-867744
• Synonyms: A-867744;4-[5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl]benzenesulfonamide
• CAS NO: 1000279-69-5
• Molecular Formula: C20H19ClN2O3S
• Molecular Weight: 402.89446
• Mol File: 1000279-69-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 610.0±65.0 °C(Predicted)
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Solubility: Soluble in DMSO
• PKA: 9.69±0.10(Predicted)
• CAS DataBase Reference: A-867744(CAS DataBase Reference)
• NIST Chemistry Reference: A-867744(1000279-69-5)
• EPA Substance Registry System: A-867744(1000279-69-5)

Safety Data

• Hazardous Substances Data: 1000279-69-5(Hazardous Substances Data)

Usage

Uses

A 867744 is a positive allosteric modulator (PAM) of α7 neuronal acetylcholine receptors, which is an interaction that is used as a therapeutic approach for managing cognitive deficits in schizophrenia and Alzheimer''s disease.

Upstream product

• 889767-08-2 ethyl 5-(4-chlorophenyl)-2-methyl-1-(4-sulfamoylphenyl)-1H-pyrrole-3-carboxylate 
• 925-90-6 ethylmagnesium bromide 

Relevant articles and documents

Heteromeric neuronal nicotinic acetylcholine receptors with mutant B subunits acquire sensitivity to A7-selective positive allosteric modulatorss

Homomeric a7 nicotinic acetylcholine receptors (nAChR) have an intrinsically low probability of opening that can be overcome by a7-selective positive allosteric modulators (PAMs), which bind at a site involving the second transmembrane domain (TM2). Mutat

PYRROLE DERIVATIVES AND THEIR METHODS OF USE

The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.