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Cas Database

100033-92-9

100033-92-9

Identification

  • Product Name:3-Bromo-2-methoxy-5-trifluoromethylpyridine

  • CAS Number: 100033-92-9

  • EINECS:

  • Molecular Weight:240.207

  • Molecular Formula:C7H5BrF3NO

  • HS Code:

  • Mol File:100033-92-9.mol

Synonyms:Bromides;((4-Bromo-3-methylphenyl)carbonyl)morpholine;(4-Bromo-3-methylphenyl)(morpholino)methanone;(3-Bromobenzoyl)pyrrolidine;(3-Bromophenyl)(pyrrolidin-1-yl)methanone;(4-Bromo-2-fluorophenyl)(4-methoxybenzyl)sulfane;S-(4-Methoxybenzyl) 4-bromo-2-fluorothiophenol;(4-Bromo-3-methylphenyl)(pyrrolidin-1-yl)methanone

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 4 Articles be found

Synthesis Utilizing Reducing Ability of Carbon Monoxide. New Methods for Synthesis of N-Substituted Selenoamides

Ogawa, Akiya,Miyake, Jun-ichi,Kambe, Nobuaki,Murai, Shinji,Sonoda, Noboru

, p. 1448 - 1451 (2007/10/02)

Convenient, one-pot syntheses of N-substituted selenoamides (2) from nitriles,metallic selenium, carbon monoxide, water, and amines have been developed on the basis of an amino-group-exchange reaction of in situ formed N-unsubstituted selenoamides (1) with primary or secondary amines.The reactions consist of two processes, i.e., the formation of selenoamides 1 by the reaction of nitriles and H2Se formed from selenium, carbon monoxide and water, and the subsequent amino-group-exchange reaction of 1 with aliphatic amines.The obtained 2 are generally stable enough to bekept for several weeks under the atmosphere of nitrogen at 0 deg C without any appreciable degradation.In the cases of primary amines, the corresponding selenoamides were also obtained from nitriles, selenium, carbon monoxide, and primary amines by a single-step mixing at the beginning of the reaction.

Convenient Syntheses of N,N-Dialkylselenoamides and N,N,N',N'-Tetraalkylselenoureas by Treating Terminal gem-Dihaloalkanes, Chloroform , or Sodium Trichloroacetate with a Base, Elemental Selenium, and Amines

Takikawa, Yuji,Yamaguchi, Minoru,Sasaki, Tohru,Ohnishi, Kenji,Shimada, Kazuaki

, p. 2105 - 2108 (2007/10/02)

Treatment of terminal gem-dihaloalkanes, chloroform or sodium trichloroacetate with elemental selenium in the presence of NaH and an excess amount of primary or secondary amines gave selenoamides and selenoureas in modest yields.

A Willgerodt-Kindler Type Selenation of Dihalomethane Derivatives, Chloroform, and Sodium Trichloroacetate by Treating with a Base, Elemental Selenium, and an Amine

Shimada, Kazuaki,Yamaguchi, Minoru,Sasaki, Tohru,Ohnishi, Kenji,Takikawa, Yuji

, p. 2235 - 2242 (2007/10/03)

Treatment of dihalomethane derivatives, chloroform, or sodium trichloroacetate with elemental selenium in the presence of NaH and an excess amount of an amine gave the corresponding selenoamides, selenoureas, and bis(selenocarbamoyl) triselenides in modest yields. These products were afforded from reactive intermediates related to "selenocarbonyl halides" and "selenophosgenoids" generated by the reaction of dichloromethanide ions and trichloromethanide ion with N-alkylated aminopolyselenide species (R2N-(Se)n-).

A new synthetic method for N-mono- and N,N-disubstituted selenoamides

Ruan, Ming-De,Zhang, Pong-Fei,Tao, Yong,Fan, Wei-Qiang

, p. 2617 - 2623 (2007/10/03)

N-Mono and N,N-disubstituted selenoamides are synthesized in a one-pot procedure from nitriles, selenium metal and NaBH4 followed by the amine group exchange of the intermediate primary selenoamide with an amine.

Process route upstream and downstream products

Process route

benzonitrile
100-47-0

benzonitrile

N,N'-di-n-butylurea
1792-17-2

N,N'-di-n-butylurea

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With selenium; carbon monoxide;Intetrahydrofuran;at 80 ℃; for 5h; under 3677.5 Torr;
0.86 g
93%
benzylidene dichloride
98-87-3

benzylidene dichloride

dibenzyl diselenide
1482-82-2

dibenzyl diselenide

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With selenium; sodium hydride;InN,N,N,N,N,N-hexamethylphosphoric triamide;at 120 ℃; for 3h;
10%
selenobenzamide
5977-82-2

selenobenzamide

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
Inwater;at 100 ℃; for 3h; Yield given;
InN,N-dimethyl-formamide;at 100 ℃; for 5h; Yield given; other solvent, temperature;
benzylidene dichloride
98-87-3

benzylidene dichloride

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; selenium; sodium hydride; at 120 ℃; for 3h;
10%
benzonitrile
100-47-0

benzonitrile

N,N'-di-n-butylurea
1792-17-2

N,N'-di-n-butylurea

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With selenium; carbon monoxide;Intetrahydrofuran;at 80 ℃; for 5h; under 3677.5 Torr;
0.86 g
93%
benzylidene dichloride
98-87-3

benzylidene dichloride

dibenzyl diselenide
1482-82-2

dibenzyl diselenide

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With selenium; sodium hydride;InN,N,N,N,N,N-hexamethylphosphoric triamide;at 120 ℃; for 3h;
10%
selenobenzamide
5977-82-2

selenobenzamide

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
Inwater;at 100 ℃; for 3h; Yield given;
InN,N-dimethyl-formamide;at 100 ℃; for 5h; Yield given; other solvent, temperature;
benzylidene dichloride
98-87-3

benzylidene dichloride

N-Butylbenzenecarboselenoamide
100033-92-9

N-Butylbenzenecarboselenoamide

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; selenium; sodium hydride; at 120 ℃; for 3h;
10%

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