1000339-30-9

Basic information

• Product Name: 2-CHLORO-6-PYRROLIDIN-1-YLPYRAZINE
• Synonyms: 2-CHLORO-6-PYRROLIDIN-1-YLPYRAZINE;1-(6-Chloropyrazin-2-yl)pyrrolidine, 2-Chloro-6-(pyrrolidin-1-yl)-1,4-diazine
• CAS NO: 1000339-30-9
• Molecular Formula: C8H10ClN3
• Molecular Weight: 183.6381
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Halides;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 1000339-30-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 313.7 °C at 760 mmHg
• Flash Point: 143.5 °C
• Appearance: /
• Density: 1.289 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.702
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-6-PYRROLIDIN-1-YLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-PYRROLIDIN-1-YLPYRAZINE(1000339-30-9)
• EPA Substance Registry System: 2-CHLORO-6-PYRROLIDIN-1-YLPYRAZINE(1000339-30-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1000339-30-9(Hazardous Substances Data)

Usage

Uses

2-Chloro-6-(pyrrolidin-1-yl)pyrazine

InChI:InChI=1/C7H5ClN4/c8-6-4-9-5-7(11-6)12-3-1-2-10-12/h1-5H

Upstream product

• 123-75-1 pyrrolidine 
• 4774-14-5 2,6-dichloropyrazine 

Relevant articles and documents

2-thioxothiazolidin-4-one analogs as pan-pim kinase inhibitors

Proviral integration site for Moloney murine leukemia virus (PIM) kinases are proto-oncogenic kinases involved in the regulation of several cellular processes. PIM kinases are promising targets for new drug development because they play a major role in many cancer-specific pathways, such as survival, apoptosis, proliferation, cell cycle regulation, and migration. Here, 2-thioxothiazolidin-4-one derivatives were synthesized and evaluated as potent pan-PIM kinase inhibitors. Optimized compounds showed single-digit nanomolar IC50 values against all three PIM kinases with high selectivity over 14 other kinases. Compound 17 inhibited the growth of Molm-16 cell lines (EC50 = 14 nM) and modulated the expression of pBAD and p4EBP1 in a dose-dependent manner.

Selective mono-amination of dichlorodiazines

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth