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1000339-30-9

1000339-30-9

Identification

  • Product Name:2-Chloro-6-(pyrrolidin-1-yl)pyrazine

  • CAS Number: 1000339-30-9

  • EINECS:

  • Molecular Weight:183.6381

  • Molecular Formula:C8H10ClN3

  • HS Code:2933990090

  • Mol File:1000339-30-9.mol

Synonyms:2-Chloro-6-pyrrolidin-1-ylpyrazine;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Abosyn
  • Product Description:2-Chloro-6-pyrrolidin-1-yl-pyrazine >95%
  • Packaging:25g
  • Price:$ 680
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Chloro-6-(pyrrolidin-1-yl)pyrazine
  • Packaging:25g
  • Price:$ 957
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:2-Chloro-6-(pyrrolidin-1-yl)pyrazine
  • Packaging:25g
  • Price:$ 717.06
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-CHLORO-6-(PYRROLIDIN-1-YL)PYRAZINE 95.00%
  • Packaging:2.5G
  • Price:$ 1147.43
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-CHLORO-6-(PYRROLIDIN-1-YL)PYRAZINE 95.00%
  • Packaging:5G
  • Price:$ 1421.65
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-CHLORO-6-(PYRROLIDIN-1-YL)PYRAZINE 95.00%
  • Packaging:1G
  • Price:$ 808.89
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:2-Chloro-6-(pyrrolidin-1-yl)pyrazine
  • Packaging:1g
  • Price:$ 122
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:2-Chloro-6-(pyrrolidin-1-yl)pyrazine
  • Packaging:5g
  • Price:$ 439
  • Delivery:In stock
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:2-Chloro-6-pyrrolidin-1-ylpyrazine 95%
  • Packaging:1gm:
  • Price:$ 106.04
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:2-Chloro-6-(1-pyrrolidinyl)pyrazine 95%
  • Packaging:10g
  • Price:$ 335
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

Selective mono-amination of dichlorodiazines

Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric

, p. 4859 - 4867 (2015/08/03)

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

BIARYL DERIVATIVE AS GPR120 AGONIST

-

Paragraph 0482, (2017/11/17)

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

2-thioxothiazolidin-4-one analogs as pan-pim kinase inhibitors

Yun, Yanghwan,Hong, Victor Sukbong,Jeong, Seungik,Choo, Hyeonseong,Kim, Shin,Lee, Jinho

, p. 854 - 861 (2021/09/06)

Proviral integration site for Moloney murine leukemia virus (PIM) kinases are proto-oncogenic kinases involved in the regulation of several cellular processes. PIM kinases are promising targets for new drug development because they play a major role in many cancer-specific pathways, such as survival, apoptosis, proliferation, cell cycle regulation, and migration. Here, 2-thioxothiazolidin-4-one derivatives were synthesized and evaluated as potent pan-PIM kinase inhibitors. Optimized compounds showed single-digit nanomolar IC50 values against all three PIM kinases with high selectivity over 14 other kinases. Compound 17 inhibited the growth of Molm-16 cell lines (EC50 = 14 nM) and modulated the expression of pBAD and p4EBP1 in a dose-dependent manner.

Process route upstream and downstream products

Process route

pyrrolidine
123-75-1

pyrrolidine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

2-chloro-6-(pyrrolidin-1-yl)pyrazine
1000339-30-9

2-chloro-6-(pyrrolidin-1-yl)pyrazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine;Indimethyl sulfoxide;at 20 ℃; for 24h;
96%
With triethylamine;Inethanol;for 2h; Reflux;
95%
With potassium carbonate;InN,N-dimethyl-formamide;at 20 ℃; Inert atmosphere;
pyrrolidine
123-75-1

pyrrolidine

2,6-dichloropyrazine
4774-14-5

2,6-dichloropyrazine

2-chloro-6-(pyrrolidin-1-yl)pyrazine
1000339-30-9

2-chloro-6-(pyrrolidin-1-yl)pyrazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine;Indimethyl sulfoxide;at 20 ℃; for 24h;
96%
With triethylamine;Inethanol;for 2h; Reflux;
95%
With potassium carbonate;InN,N-dimethyl-formamide;at 20 ℃; Inert atmosphere;

Global suppliers and manufacturers

Global( 14) Suppliers
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  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
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  • Emails:sales@amadischem.com
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  • Career Henan Chemical Co
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  • Emails:purchase@coreychem.com
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  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
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  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:151
  • Country:China (Mainland)
  • Boc Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
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  • Country:United States
  • ENAO Chemical Co, Limited
  • Business Type:Lab/Research institutions
  • Contact Tel:86--15307605669
  • Emails:sales@enaochem.com
  • Main Products:1
  • Country:China (Mainland)
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