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Cas Database

1000341-18-3

1000341-18-3

Identification

  • Product Name:3-Amino-5-cyanobenzoic acid

  • CAS Number: 1000341-18-3

  • EINECS:

  • Molecular Weight:162.15

  • Molecular Formula: C8H6N2O2

  • HS Code:

  • Mol File:1000341-18-3.mol

Synonyms:3-Amino-5-cyanobenzoic acid

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:3-Amino-5-cyanorobenzoicAcid
  • Packaging:10mg
  • Price:$ 130
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:ChemScene
  • Product Description:3-Amino-5-cyanobenzoicacid >97.0%
  • Packaging:250mg
  • Price:$ 125
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:ChemScene
  • Product Description:3-Amino-5-cyanobenzoicacid >97.0%
  • Packaging:100mg
  • Price:$ 75
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:3-Amino-5-cyanobenzoicacid >97.0%
  • Packaging:1g
  • Price:$ 250
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:3-Amino-5-cyanobenzoic acid >97%
  • Packaging:250mg
  • Price:$ 230
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei

Bu?yszko, Ilona,Dr?ger, Gerald,Klenge, Anja,Kirschning, Andreas

supporting information, p. 19231 - 19242 (2016/01/26)

Supplementing an AHBA(-) mutant strain of Amycolatopsis mediterranei, the rifamycin producer, with a series of benzoic acid derivatives yielded new tetraketides containing different phenyl groups. These mutasynthetic studies revealed unique reductive properties of A. mediterranei towards nitro- and azidoarenes, leading to the corresponding anilines. In selected cases, the yields of mutaproducts (fermentation products isolated after feeding bacteria with chemically prepared analogs of natural building blocks) obtained are in a range (up to 118 mg L-1) that renders them useful as chiral building blocks for further synthetic endeavors. The configuration of the stereogenic centers at C6 and C7 was determined to be 6R,7S for one representative tetraketide. Importantly, processing beyond the tetraketide stage is not always blocked when the formation of the bicyclic naphthalene precursor cannot occur. This was proven by formation of a bromo undecaketide, an observation that has implications regarding the evolutionary development of rifamycin biosynthesis.

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

Nuss, Jonathan E.,Dong, Yuxiang,Wanner, Laura M.,Ruthel, Gordon,Wipf, Peter,Gussio, Rick,Vennerstrom, Jonathan L.,Bavari, Sina,Burnett, James C.

scheme or table, p. 301 - 305 (2010/12/25)

Botulinum neurotoxins (BoNTs) are the deadliest of microbial toxins. The enzymes' zinc(II) metalloprotease, referred to as the light chain (LC) component, inhibits acetylcholine release into neuromuscular junctions, resulting in the disease botulism. Curr

Process route upstream and downstream products

Process route

3-cyano-5-nitrobenzoic acid
98556-65-1

3-cyano-5-nitrobenzoic acid

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
3-cyano-5-nitrobenzoic acid; With palladium 10% on activated carbon; ammonium formate; In water; at 90 ℃; for 21h;
With formic acid; In water;
77%
methyl 3-amino-5-cyanobenzoate
199536-01-1

methyl 3-amino-5-cyanobenzoate

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
With lithium hydroxide; In methanol; water; at 20 ℃; for 2h;
78%
methyl 3-cyano-5-nitrobenzoate
99066-80-5

methyl 3-cyano-5-nitrobenzoate

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: tin(II) chloride dihdyrate; acetic acid / ethyl acetate / 1.5 h / Reflux
2: lithium hydroxide / methanol; water / 2 h / 20 °C
With tin(II) chloride dihdyrate; acetic acid; lithium hydroxide; In methanol; water; ethyl acetate;
3-cyano-5-nitrobenzoic acid
98556-65-1

3-cyano-5-nitrobenzoic acid

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
3-cyano-5-nitrobenzoic acid; With palladium 10% on activated carbon; ammonium formate; In water; at 90 ℃; for 21h;
With formic acid; In water;
77%
methyl 3-amino-5-cyanobenzoate
199536-01-1

methyl 3-amino-5-cyanobenzoate

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
With lithium hydroxide; In methanol; water; at 20 ℃; for 2h;
78%
methyl 3-cyano-5-nitrobenzoate
99066-80-5

methyl 3-cyano-5-nitrobenzoate

C<sub>8</sub>H<sub>6</sub>N<sub>2</sub>O<sub>2</sub>
1000341-18-3

C8H6N2O2

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: tin(II) chloride dihdyrate; acetic acid / ethyl acetate / 1.5 h / Reflux
2: lithium hydroxide / methanol; water / 2 h / 20 °C
With tin(II) chloride dihdyrate; acetic acid; lithium hydroxide; In methanol; water; ethyl acetate;

Global suppliers and manufacturers

Global( 2) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
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