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Cas Database

1000341-27-4

1000341-27-4

Identification

  • Product Name:1H-Indazole, 3-iodo-6-(trifluoromethyl)-

  • CAS Number: 1000341-27-4

  • EINECS:

  • Molecular Weight:312.033

  • Molecular Formula:C8H4F3IN2

  • HS Code:

  • Mol File:1000341-27-4.mol

Synonyms:3-IODO-6-(TRIFLUOROMETHYL)-INDAZOLE;1H-INDAZOLE,3-IODO-6-(TRIFLUOROMETHYL);3-Iodo-6-(trifluoromethyl)-1H-indazole;6-Trifluoromethyl-3-iodo-1H-indazole;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:AK Scientific
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole
  • Packaging:1g
  • Price:$ 401
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Alichem
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole
  • Packaging:5g
  • Price:$ 1090.98
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole 98%
  • Packaging:100mg
  • Price:$ 39
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole 98%
  • Packaging:1g
  • Price:$ 142
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole 98%
  • Packaging:250mg
  • Price:$ 142
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:3-IODO-6-(TRIFLUOROMETHYL) (1H)INDAZOLE 95.00%
  • Packaging:0.25G
  • Price:$ 350
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole 98%
  • Packaging:1g
  • Price:$ 295
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole 98%
  • Packaging:1g
  • Price:$ 312
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:3-Iodo-6-(trifluoromethyl)-1H-indazole
  • Packaging:1mg
  • Price:$ 45
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors

Bergan, Raymond,Clutter, Matthew R.,Deibler, Kristine K.,Fowler, Graham,George, Mariam Donny,Gordon, Ryan,Mishra, Rama K.,O'Connor, Matthew,Scheidt, Karl A.,Schiltz, Gary E.,Vagadia, Purav P.

supporting information, p. 615 - 620 (2019/02/25)

Herein we report the discovery of a novel series of highly potent and selective mitogen-activated protein kinase kinase 4 (MEK4) inhibitors. MEK4 is an upstream kinase in MAPK signaling pathways that phosphorylates p38 MAPK and JNK in response to mitogenic and cellular stress queues. MEK4 is overexpressed and induces metastasis in advanced prostate cancer lesions. However, the value of MEK4 as an oncology target has not been pharmacologically validated because selective chemical probes targeting MEK4 have not been developed. Optimization of this series via structure–activity relationships and molecular modeling led to the identification of compound 6 ff (4-(6-fluoro-2H-indazol-3-yl)benzoic acid), a highly potent and selective MEK4 inhibitor. This series of inhibitors is the first of its kind in both activity and selectivity and will be useful in further defining the role of MEK4 in prostate and other cancers.

INDAZOLYL-ISOXAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER

-

Page/Page column 65-66, (2020/08/28)

Compounds of the formula (I) in which R1, R2, X, Y and Z have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.

Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP1 receptor antagonist and in vivo studies in a bone fracture model

Atobe, Masakazu,Naganuma, Kenji,Kawanishi, Masashi,Hayashi, Takahiko,Suzuki, Hiroko,Nishida, Masahiro,Arai, Hirokazu

supporting information, p. 2408 - 2412 (2018/06/26)

We describe a medicinal chemistry approach to the discovery of a novel EP1 antagonist exhibiting high potency and good pharmacokinetics. Our starting point is 1, an EP1 receptor antagonist that exhibits pharmacological efficacy in cy

Design, synthesis and structure–activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK)

Wang, Xueying,Xue, Gang,Pan, Zhengying

, (2019/12/11)

Interleukin-2 inducible T-cell kinase (ITK), a member of the Tec family of tyrosine kinases, plays an important role in T cell signaling downstream of the T-cell receptor (TCR). Herein we report the discovery of a series of indolylindazole based covalent ITK inhibitors with nanomolar inhibitory potency against ITK, good kinase selectivity and potent inhibition of the phosphorylation of PLCγ1 and ERK1/2 in living cells. A computational study provided insight into the interactions between inhibitors and Phe437 at the ATP binding pocket of ITK, suggesting that both edge-to-face π-π interaction and the dihedral torsion angle contribute to inhibitors’ potency. Compounds 43 and 55 stood out as selective covalent inhibitors with potent cellular activity, which could be used as chemical tools for further study of ITK functions.

BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS

-

Page/Page column 39-40, (2010/03/02)

A nitrogen-containing bicyclic heterocyclic compound represented by the following formula (1) is provided. When the compound or a salt thereof is administered to a human being or an animal, the compound has a strong antagonistic action against EP1 recepto

Process route upstream and downstream products

Process route

6-(trifluoromethyl)-1H-indazole
954239-22-6

6-(trifluoromethyl)-1H-indazole

3-iodo-6-(trifluoromethyl)-1H-indazole
1000341-27-4

3-iodo-6-(trifluoromethyl)-1H-indazole

Conditions
ConditionsYield
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 3h;
83%
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 3h;
With iodine; potassium carbonate;InN,N-dimethyl-formamide;at 20 ℃; for 3h; regioselective reaction;
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 18h;
2-Fluoro-4-(trifluoromethyl)benzaldehyde
89763-93-9

2-Fluoro-4-(trifluoromethyl)benzaldehyde

3-iodo-6-(trifluoromethyl)-1H-indazole
1000341-27-4

3-iodo-6-(trifluoromethyl)-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: O-Methylhydroxylamin / tetrahydrofuran / 3 h / 20 °C
1.2: 3 h / 80 °C
2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 3 h / 20 °C
With O-Methylhydroxylamin; iodine; potassium hydroxide;Intetrahydrofuran; N,N-dimethyl-formamide;
6-(trifluoromethyl)-1H-indazole
954239-22-6

6-(trifluoromethyl)-1H-indazole

3-iodo-6-(trifluoromethyl)-1H-indazole
1000341-27-4

3-iodo-6-(trifluoromethyl)-1H-indazole

Conditions
ConditionsYield
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 3h;
83%
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 3h;
With iodine; potassium carbonate;InN,N-dimethyl-formamide;at 20 ℃; for 3h; regioselective reaction;
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;
With iodine; potassium hydroxide;InN,N-dimethyl-formamide;at 20 ℃; for 18h;
2-Fluoro-4-(trifluoromethyl)benzaldehyde
89763-93-9

2-Fluoro-4-(trifluoromethyl)benzaldehyde

3-iodo-6-(trifluoromethyl)-1H-indazole
1000341-27-4

3-iodo-6-(trifluoromethyl)-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: O-Methylhydroxylamin / tetrahydrofuran / 3 h / 20 °C
1.2: 3 h / 80 °C
2.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 3 h / 20 °C
With O-Methylhydroxylamin; iodine; potassium hydroxide;Intetrahydrofuran; N,N-dimethyl-formamide;

Global suppliers and manufacturers

Global( 8) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
  • Yinghao Pharm Co.,Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-519-85390519
  • Emails:sales@haopharm.com
  • Main Products:1
  • Country:China (Mainland)
  • Tianjin SPHINX SCIENTIFIC LAB.
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-022-66211289
  • Emails:sales1@sphinxscientificlab.com
  • Main Products:1
  • Country:China (Mainland)
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