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1000341-42-3

1000341-42-3

Identification

  • Product Name:5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER

  • CAS Number: 1000341-42-3

  • EINECS:

  • Molecular Weight:250.211

  • Molecular Formula:C11H10N2O5

  • HS Code:

  • Mol File:1000341-42-3.mol

Synonyms:5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER;methyl 5-methoxy-7-nitro-1H-indole-2-carboxylate

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER 95.00%
  • Packaging:5MG
  • Price:$ 496.51
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:Methyl5-methoxy-7-nitro-1H-indole-2-carboxylate 95%
  • Packaging:1g
  • Price:$ 425
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Methyl5-methoxy-7-nitro-1H-indole-2-carboxylate 95+%
  • Packaging:1g
  • Price:$ 451
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:5-Methoxy-7-nitro-2-indolecarboxylicAcidMethylEster
  • Packaging:10mg
  • Price:$ 155
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Song, Jeong Uk,Jang, Jae Wan,Kim, Tae Hun,Park, Heuisul,Park, Wan Su,Jung, Sang-Hun,Kim, Geun Tae

, p. 950 - 954 (2016/05/24)

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

-

Page/Page column 19, (2010/08/22)

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

-

Page/Page column 63, (2009/04/25)

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

-

Page/Page column 21, (2010/11/03)

The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

-

Page/Page column 71, (2009/07/25)

The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

Process route upstream and downstream products

Process route

C<sub>11</sub>H<sub>13</sub>N<sub>3</sub>O<sub>5</sub>

C11H13N3O5

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With polyphosphoric acid; at 70 ℃;
4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium nitrite
2: sodium acetate
3: polyphosphoric acid / 70 °C
With hydrogenchloride; sodium acetate; sodium nitrite;
4-methoxy-2-nitrophenylhydrazine
61690-45-7

4-methoxy-2-nitrophenylhydrazine

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate
2: polyphosphoric acid / 70 °C
With sodium acetate;
5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
27%
27%
C<sub>11</sub>H<sub>13</sub>N<sub>3</sub>O<sub>5</sub>

C11H13N3O5

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With polyphosphoric acid; at 70 ℃;
4-methoxy-2-nitroaniline
96-96-8

4-methoxy-2-nitroaniline

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride; sodium nitrite
2: sodium acetate
3: polyphosphoric acid / 70 °C
With hydrogenchloride; sodium acetate; sodium nitrite;
4-methoxy-2-nitrophenylhydrazine
61690-45-7

4-methoxy-2-nitrophenylhydrazine

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate
2: polyphosphoric acid / 70 °C
With sodium acetate;
5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester
1000341-42-3

5-methoxy-7-nitro-1H-indole-2-carboxylic acid methyl ester

Conditions
ConditionsYield
27%
27%

Global suppliers and manufacturers

Global( 7) Suppliers
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  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:28
  • Country:China (Mainland)
  • Debye Scientific
  • Business Type:Trading Company
  • Contact Tel:00852-21376140
  • Emails:sales@debyesci.com
  • Main Products:13
  • Country:China (Mainland)
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