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1000341-42-3

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1000341-42-3 Usage

General Description

5-Methoxy-7-nitro-2-indolecarboxylic acid methyl ester is a chemical compound with the molecular formula C12H10N2O6. It is a yellow crystalline solid that is used in organic synthesis and pharmaceutical research. 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID METHYL ESTER has been studied for its potential biological and pharmacological properties, including its anti-inflammatory and anti-cancer activities. It is a methyl ester derivative of 5-methoxy-7-nitro-2-indolecarboxylic acid, and it is commonly used as a building block in the synthesis of various organic compounds. Additionally, it can serve as a precursor for the preparation of novel drugs and bioactive molecules with potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1000341-42-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,3,4 and 1 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1000341-42:
(9*1)+(8*0)+(7*0)+(6*0)+(5*3)+(4*4)+(3*1)+(2*4)+(1*2)=53
53 % 10 = 3
So 1000341-42-3 is a valid CAS Registry Number.

1000341-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 5-methoxy-7-nitro-1H-indole-2-carboxylate

1.2 Other means of identification

Product number -
Other names 7-Methyl-5-methoxy isatin 7-Methyl-5-methoxy indole-2,3-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1000341-42-3 SDS

1000341-42-3Relevant articles and documents

Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors

Song, Jeong Uk,Jang, Jae Wan,Kim, Tae Hun,Park, Heuisul,Park, Wan Su,Jung, Sang-Hun,Kim, Geun Tae

, p. 950 - 954 (2016/05/24)

Inhibition of xanthine oxidase (XO) has obviously been a central concept for controlling hyperuricemia, which causes serious and painful inflammatory arthritis disease such as gout. We discovered a series of novel 2-(indol-2-yl)thiazole derivatives as XO inhibitors at the level of nanomolar activity. Structure-guided design using molecular modeling program (Accelrys Software program) provided an excellent basis for optimization of 2-(indol-2-yl)thiazole compounds. Structure-activity relationship indicated that hydrophobic alkoxy group (isopropoxy, cyclopentoxy) at 5-position and hydrogen binding acceptor (NO2, CN) at 7-position of indole ring appear as critical functional groups. Among the compounds, 2-(7-nitro-5-isopropoxy-indol-2-yl)-4-methylthiazole-5-carboxylic acid (9m) exhibits the most potent XO inhibitory activity (IC50value: 5.1 nM) and the excellent uric acid lowering activity in potassium oxonate induced hyperuricemic rat model.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

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Page/Page column 19, (2010/08/22)

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

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Page/Page column 63, (2009/04/25)

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

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