100037-55-6

Basic information

• Product Name: N-phenethyl-N'-(2-thiazolyl)-N'-ethylmalonamide
• CAS NO: 100037-55-6
• Molecular Weight: 317.412
• Mol File: 100037-55-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenethyl-N'-(2-thiazolyl)-N'-ethylmalonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenethyl-N'-(2-thiazolyl)-N'-ethylmalonamide(100037-55-6)
• EPA Substance Registry System: N-phenethyl-N'-(2-thiazolyl)-N'-ethylmalonamide(100037-55-6)

Safety Data

• Hazardous Substances Data: 100037-55-6(Hazardous Substances Data)

Upstream product

• 13472-75-8 2-(2-Aminoethyl)-thiazole 
• 79147-32-3 anhydro(8-ethyl-5-hydroxy-7-oxothiazolo<3,2-a>pyrimidinium hydroxide) 
• 64-04-0 phenethylamine 

Relevant articles and documents

Studies of Amine-Induced Ring Opening of Some Mesoionic Xanthines

The ring-opening reactions of seven mesoionic thiazolopyrimidine-5,7-diones by a series of primary and secondary amines have been investigated.The rates of the ring fission of five N(8)-substituted mesoionic xanthines with benzylamine were measured and found to follow second order kinetics.The Hammett relationship is followed with ρ value of +0.48 in p-dioxane as solvent.The dependence of rates on temperatures has been studied for the N(8)-ethyl derivative; the energy of activation (ΔE*) is 25.3 kcals mol-1, the enthalpy of activation (ΔH*) is 24.7 kcals mo l -1 and the entropy of activation (ΔS*) is -4.9 e.u.A slight increase in rate of reaction was observed when the solvent was changed from p-dioxane to dimethyl sulfoxide.In p-dioxane at constant mesoionic xanthine concentration, the rate constant for ring opening decreased with increasing benzylamine concentration.These results are consistent with a bimolecular nucleophilic mechanism proceeding by the rate-determining formation of a charged tetrahedral transition state.