100042-33-9Relevant articles and documents
Synthesis and evaluation of caffeic acid amides as antioxidants
Rajan, Padinchare,Vedernikova, Irina,Cos, Paul,Vanden Berghe, Dirk,Augustyns, Koen,Haemers, Achiel
, p. 215 - 217 (2001)
A series of amides of caffeic acid has been synthesised and their antioxidant properties evaluated as lipid peroxidation inhibitors. Anilides of caffeic acid were found to be very efficient antioxidants with IC50's of 0.3 μM.
Design, synthesis and biological evaluation of caffeic acid amides as selective MMP-2 and MMP-9 inhibitors
Shi, Zhi-Hao,Li, Nian-Guang,Shi, Qian-Ping,Tang, Hao,Tang, Yu-Ping,Li, Wei,Yin, Lian,Yang, Jian-Ping,Duan, Jin-Ao
, p. 343 - 351 (2012/10/29)
Strategy, Management and Health Policy Preclinical Research A series of caffeic acid amides with extended P1' groups were synthesized and tested for their inhibitory activities on matrix metalloproteinase (MMP)-1, MMP-2, and MMP-9. Compound 3f showed considerable inhibitory activities against MMP-2, MMP-9, and best selectivity over MMP-1. Preliminary structure-activity relationship analysis and docking studies indicated that caffeic acid amides with electron-donating groups at p-position of amino phenyl group showed better inhibitory activities and selectivity than those with electron-withdrawing groups. The findings of this study would provide information for the exploitation and utilization of caffeic acid as MMP inhibitor for metastatic tumor treatment.