100042-36-2

Basic information

• Product Name: 2-Propenamide,3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)-, (2E)-
• Synonyms: 2-Propenamide,3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)-, (E)-; TMK 913
• CAS NO: 100042-36-2
• Molecular Formula: C16H15 N O4
• Molecular Weight: 285.299
• Mol File: 100042-36-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenamide,3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide,3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)-, (2E)-(100042-36-2)
• EPA Substance Registry System: 2-Propenamide,3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)-, (2E)-(100042-36-2)

Safety Data

• Hazardous Substances Data: 100042-36-2(Hazardous Substances Data)

Usage

Also known as

(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenyl)prop-2-enamide

Derivative of

hydroxycinnamic acid

Appearance

white to off-white crystalline powder

Uses

antioxidant and anti-inflammatory properties in pharmaceutical and cosmetic industries
Studied for potential therapeutic applications in treating various diseases and conditions, including cancer

Upstream product

• 123-30-8 4-amino-phenol 
• 121-33-5 vanillin 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 

Relevant articles and documents

An alternative way to analogues of avenanthramides and their antiradical activity

Abstract: The paper is devoted to the synthesis of arylidene malonic acid monoanilides and cinnamoyl anilines by condensation of malonic acid monoanilides with aromatic aldehydes. The presented synthetic route applies simple, cheap, and commercially available aromatic aldehydes and amines, thus overcoming traditional schemes, which involve derivatives of hydroxycinnamic acids. Besides, a mild and effective pyridine-mediated decarboxylation of carboxylic group at Csp2 in arylidene malonic acid monoanilides leading to cinnamoyl anilines is presented. The structures of obtained selected arylidene derivatives were approved additionally by X-ray analysis. The antiradical properties (2,2-diphenyl-1-picrylhydrazyl and galvinoxyl tests) and structure–activity relationships of the synthesized compounds were studied. Graphical abstract: [Figure not available: see fulltext.].