100044-70-0Relevant articles and documents
Quinine-catalyzed highly enantioselective cycloannulation of o-quinone methides with malononitrile
Adili, Alafate,Tao, Zhong-Lin,Chen, Dian-Feng,Han, Zhi-Yong
, p. 2247 - 2250 (2015/03/04)
2-Amino-3-cyano-4H-chromenes show great potential as novel anticancer agents. Here we report a quinine-catalyzed highly enantioselective formal 4 + 2 cycloaddition of ortho-quinone methides and malononitrile, providing a unique approach to 4-arylvinyl, 4-aryl and 4-vinyl 2-amino-3-cyano-4H-chromenes with excellent yields and enantioselectivities. Moreover, this reaction can be performed in up to 6 mmol scale without any noticeable loss of yield and stereoselectivity. This journal is
A New Generation of o-Quinone Methides from o-(1-(Alkylthio)alkyl)phenols under Mild Conditions
Inoue, Tsutomu,Inoue, Seiichi,Sato, Kikumasa
, p. 653 - 656 (2007/10/02)
o-(1-(Alkylthio)alkyl)phenols are converted into o-quinone methides in good yield by treatment with silver oxide under mild conditions.Since the methides tend to prefer (E) configuration, cis-4-alkyl-2-alkoxychromans are exclusively obtained as a result o
