100046-94-4Relevant articles and documents
ERβ ligands. Part 5: Synthesis and structure-activity relationships of a series of 4′-hydroxyphenyl-aryl-carbaldehyde oxime derivatives
Mewshaw, Richard E.,Bowen, S. Marc,Harris, Heather A.,Xu, Zhang B.,Manas, Eric S.,Cohn, Stephen T.
, p. 902 - 906 (2007/10/03)
A series of 4′-hydroxyphenyl-aryl-carbaldehyde oximes (5b) was prepared and found to have high affinity (4 nM) and modest selectivity (39-fold) for estrogen receptor-β (ERβ). Substitution of one of the core rings of the scaffold based around these novel ligands further expanded our knowledge in the quest toward achieving high affinity and selectivity for ERβ. An X-ray co-crystal of structure 11 revealed that the oxime moiety was mimicking the C-ring of genistein, as previously predicted by SAR and docking studies.
Synthesis of Enol Lactones of 3-Aroyl-2-(thienylmethylene)-propionic Acids and their Conversion into the Corresponding 4-Arylbenzothiophene-6-carboxylic Acids
Guirguis, Nadia R.,Awad, Boshra M.,Saad, Hanaa A.
, p. 1003 - 1011 (2007/10/02)
Heterocyclic aldehydes such as 2-thiophenecarbaldehyde (1) condense with 3-aroylpropionic acids 2 or their sodium salts to give the enol lactones 3a-d of 3-aroyl-2-(2-thienylmethylene)propionic acids.Isomerization of 3a-d leads to the corresponding 4-aryl
