100063-41-0

Basic information

• Product Name: "5-Methyl-2-phenyl-oxazole-4-carboxylic acid Methyl ester
• Synonyms: "5-Methyl-2-phenyl-oxazole-4-carboxylic acid Methyl ester;Methyl 5-methyl-2-phenyl-1,3-oxazole-4-carboxylate;METHYL 5-METHYL-2-PHENYLOXAZOLE-4-CARBOXYLATE
• CAS NO: 100063-41-0
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.23
• EINECS: -0
• Mol File: 100063-41-0.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: "5-Methyl-2-phenyl-oxazole-4-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: "5-Methyl-2-phenyl-oxazole-4-carboxylic acid Methyl ester(100063-41-0)
• EPA Substance Registry System: "5-Methyl-2-phenyl-oxazole-4-carboxylic acid Methyl ester(100063-41-0)

Safety Data

• Hazardous Substances Data: 100063-41-0(Hazardous Substances Data)

Usage

Uses

5-Methyl-2-phenyloxazole-4-carboxylic Acid Methyl Ester is an intermediate used to prepare 2-Phenyl-5-methyloxazole-4-carboxylic Acid (P336070) which is a building block used to prepare oxazole transthyretin amyloidogenesis inhibitors. 2-Phenyl-5-methyloxazole-4-carboxylic Acid is also used to synthesize inhibitors of HldE kinase as Gram-negative antivirulence drugs.

Upstream product

• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 65-85-0 benzoic acid 
• 82659-84-5 (4S,5S)-5-methyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester 
• 1242683-14-2 (Z)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester 
• 55-21-0 benzamide 
• 99990-33-7 (E)-N-benzoyl-β-bromo-2,3-dehydro-2-aminobutyric acid methyl ester 
• 1084941-24-1 Bz-Z-ΔAbu(β-I)-OMe 
• 105-45-3 acetoacetic acid methyl ester 
• 100-46-9 benzylamine 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 60027-58-9 (Z)-α-N-benzoylamino-2-butenoic acid methylester 
• 87413-09-0 Dess-Martin periodane 
• 18735-67-6 1-(5-methyl-3-oxy-2-phenyl-oxazol-4-yl)-ethanone; hydrochloride 
• 2940-19-4 4-acetyl-5-methyl-2-phenyloxazole 

Downstream Products

• 5221-67-0 5-methyl-2-phenyloxazole 
• 18735-74-5 5-methyl-2-phenyloxazole-4-carboxylic acid 

Relevant articles and documents

Solid-phase rhodium carbenoid reactions: an N-H insertion route to a diverse series of oxazoles.

[reaction: see text] The solid-phase synthesis of a series of oxazoles is described. The key step in the construction of these molecules involves the rhodium-catalyzed decomposition of polymer-bound alpha-diazo-beta-ketoesters. These reactions are performed in the presence of primary amides and yield the corresponding N-H insertion products. Subsequent cyclodehydration of these alpha-(acylamino)-beta-ketoesters provides the corresponding resin-bound 2,5-disubstituted oxazoles, which are further elaborated during cleavage from the resin.

Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines

An electrochemical method for synthesizing 1,2,4,5-tetrasubstituted imidazoles was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochemical C(sp3)-H aminationviaenamines and amines. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAAreceptor analogs.

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor. The

Electrochemically promoted synthesis of polysubstituted oxazoles from β-diketone derivatives and benzylamines under mild conditions

An efficient electrochemical synthesis of poly-substituted oxazoles from readily available β-diketone derivatives and benzylamines is described. This electrochemical procedure does not need hazardous oxidants and transition metal catalysts as well as molecular I2 additives. Compared with the traditional thermo-chemical method, the present electrochemical method is greener and more efficient. The Royal Society of Chemistry 2014.