100074-41-7

Basic information

• Product Name: 3-(2-chlorophenyl)-4-hydroxyfuran-2(5H)-one
• Synonyms: 3-(2-chlorophenyl)-4-hydroxyfuran-2(5H)-one
• CAS NO: 100074-41-7
• Molecular Weight: 210.617
• Mol File: 100074-41-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(2-chlorophenyl)-4-hydroxyfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-4-hydroxyfuran-2(5H)-one(100074-41-7)
• EPA Substance Registry System: 3-(2-chlorophenyl)-4-hydroxyfuran-2(5H)-one(100074-41-7)

Safety Data

• Hazardous Substances Data: 100074-41-7(Hazardous Substances Data)

Upstream product

• 2444-36-2 2'-chloro-benzeneacetic acid 
• 96-35-5 glycolic acid methyl ester 
• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 25974-09-8 sodium 2-chlorophenylethanoate 
• 100074-28-0 (2-Chloro-phenyl)-acetic acid ethoxycarbonylmethyl ester 

Downstream Products

• 1504594-05-1 C₁₂H₁₀BrClO₃ 
• 1514776-50-1 7-(4-(2-(3-(2-chlorophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1514776-46-5 7-(4-(2-(3-(2-chlorophenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 100074-68-8 5-Bromo-3-(2-chloro-phenyl)-4-methoxy-5H-furan-2-one 
• 100074-54-2 3-(2-chlorophenyl)-4-methoxy-5H-furan-2-one 

Relevant articles and documents

Synthesis and bio-evaluation of natural butenolides-acrylate conjugates

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L?1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

3-Arylfuran-2(5H)-one, a novel antibacterial pharmacophore targeting tyrosyl-tRNA synthetase (TyrRS), was hybridized with the clinically used fluoroquinolones to give a series of novel multi-target antimicrobial agents. Thus, twenty seven 3-arylfuran-2(5H)-one-fluoroquinolone hybrids were synthesized and evaluated for their antimicrobial activities. Some of the hybrids exhibited merits from both parents, displaying a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria. The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin. The enzyme assays reveal that 11 is a potent multi-target inhibitor with IC50 of 1.15 ± 0.07 μM against DNA gyrase and 0.12 ± 0.04 μM against TyrRS, respectively. Its excellent inhibitory activities against isolated enzymes and intact cells strongly suggest that 11 deserves to further research as a novel antibiotic.