100074-53-1

Basic information

• Product Name: 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one
• Synonyms: 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one
• CAS NO: 100074-53-1
• Molecular Weight: 190.199
• Mol File: 100074-53-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one(100074-53-1)
• EPA Substance Registry System: 3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one(100074-53-1)

Safety Data

• Hazardous Substances Data: 100074-53-1(Hazardous Substances Data)

Upstream product

• 96-35-5 glycolic acid methyl ester 
• 23786-13-2 methyl p-tolylacetate 
• 99-94-5 p-Toluic acid 
• 98026-98-3 3-Diazotetrahydrofuran-2,4-dione 
• 108-88-3 toluene 
• 25307-01-1 p-tolylacetic acid sodium salt 
• 622-47-9 4-tolylacetic acid 
• 100074-40-6 phenylacetic acid 

Downstream Products

• 1504595-20-3 C₁₃H₁₃BrO₃ 
• 1514777-73-1 7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1514777-75-3 7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 100074-66-6 4-methoxy-3-(4-methylphenyl)-5H-furan-2-one 
• 1421237-15-1 C₂₃H₂₄FNO₅ 

Relevant articles and documents

Compound, as well as preparation method and application thereof

The application discloses a compound of which the structure is represented as the following formula, wherein R1 is selected from any one of F, Cl, Br, C1-C5 alkyl group, and a group having the structure as the formula (1), n = 0, 1, 2, 3, 4 or 5; the R2 is selected from any one of a group having the structure as the formula (1), a group having the structure as the formula (2), and a group having the structure as the formula (3). The compound has simple preparation method, can be used as a neuraminidase inhibitor, and has excellent antivirus activity.

Catalytic Undirected Intermolecular C-H Functionalization of Arenes with 3-Diazofuran-2,4-dione: Synthesis of 3-Aryl Tetronic Acids, Vulpinic Acid, Pinastric Acid, and Methyl Isoxerocomate

A variety of 3-aryl tetronic acids have been synthesized by an undirected, intermolecular C-H functionalization of arenes with 3-diazofuran-2,4-dione. This methodology featured as a key step in the synthesis of a series of naturally occurring 3-aryl-5-arylidene tetronic acids (pulvinates) from commercially available tetronic acid. Salient features of the pulvinic acid synthesis include a one-step, stereoselective synthesis of the C5 arylidene group and a single step introduction of the C3 aryl substituent.

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

3-Arylfuran-2(5H)-one, a novel antibacterial pharmacophore targeting tyrosyl-tRNA synthetase (TyrRS), was hybridized with the clinically used fluoroquinolones to give a series of novel multi-target antimicrobial agents. Thus, twenty seven 3-arylfuran-2(5H)-one-fluoroquinolone hybrids were synthesized and evaluated for their antimicrobial activities. Some of the hybrids exhibited merits from both parents, displaying a broad spectrum of activity against resistant strains including both Gram-negative and Gram-positive bacteria. The most potent compound (11) in antibacterial assay shows MIC50 of 0.11 μg/mL against Multiple drug resistant Escherichia coli, being about 51-fold more potent than ciprofloxacin. The enzyme assays reveal that 11 is a potent multi-target inhibitor with IC50 of 1.15 ± 0.07 μM against DNA gyrase and 0.12 ± 0.04 μM against TyrRS, respectively. Its excellent inhibitory activities against isolated enzymes and intact cells strongly suggest that 11 deserves to further research as a novel antibiotic.