1000802-51-6

Basic information

• Product Name: C₁₆H₂₈BN₃O₂
• CAS NO: 1000802-51-6
• Molecular Weight: 305.228
• Mol File: 1000802-51-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₈BN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₈BN₃O₂(1000802-51-6)
• EPA Substance Registry System: C₁₆H₂₈BN₃O₂(1000802-51-6)

Safety Data

• Hazardous Substances Data: 1000802-51-6(Hazardous Substances Data)

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 

Relevant articles and documents

Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors

Never in mitosis (NIMA) related kinase 2 (Nek2) is involved in multiple cellular processes such as cell cycle checkpoint regulation, cell division, DNA damage response and cell apoptosis. Nek2 has been reported to be overexpressed in various tumors and correlated with poor prognosis. Herein, a series of imidazo[1,2-a] pyridines Nek2 inhibitors were designed, synthesized, and their biological activities were investigated. Besides, structure activity relationship analysis of these compounds were performed in the MGC-803 cell. The screening results are promising, and compound 28e shows good proliferation inhibitory activity with an IC50 of 38 nM. The results would be helpful to design and develop more effective Nek2 inhibitors for the treatment of gastric cancer.