1000865-32-6

Basic information

• Product Name: 3-acetyl-5-methyl-2-(4-nitrophenyl)-1,3,4-oxadiazoline
• Synonyms: 3-acetyl-5-methyl-2-(4-nitrophenyl)-1,3,4-oxadiazoline
• CAS NO: 1000865-32-6
• Molecular Weight: 249.226
• Mol File: 1000865-32-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-acetyl-5-methyl-2-(4-nitrophenyl)-1,3,4-oxadiazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-5-methyl-2-(4-nitrophenyl)-1,3,4-oxadiazoline(1000865-32-6)
• EPA Substance Registry System: 3-acetyl-5-methyl-2-(4-nitrophenyl)-1,3,4-oxadiazoline(1000865-32-6)

Safety Data

• Hazardous Substances Data: 1000865-32-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 

Downstream Products

• 22815-99-2 2-methyl-5-(4-nitrophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part III. [1,2] Transformation of N,O-acetals: 3-Acyl-1,3,4-oxadiazolines

(Chemical Equation Presented) Various aldehyde and ketone acylhydrazones are synthesized and, under acylating conditions, cyclized into 3-acyl-1,3,4-oxadiazolines. The scope and limitations of these cyclizations and the possible side reactions (e.g. formation of the open-chain N,O-acylhydrazinocarbinols) are dissected. For the first time, simple, convenient and efficient dehydrogenations of 3-acyl-1,3,4-oxadiazolines to oxadiazoles by treatment with potassium permanganate, or more conveniently, with ammonium cerium(IV) nitrate (CAN) are presented. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-oxadiazolines, as well as that of aldehyde diacylhydrazones (open-chain isomers of 2,5-disubstituted 3-acyl-1,3,4- oxadiazolines) regenerates the parent carbonyl compounds.