1000994-95-5Relevant articles and documents
Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
Ahunovych, Volodymyr,Boretskyi, Andrii,Bugera, Maksym,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Razhyk, Bohdan,Semenov, Sergey,Tarasenko, Karen,Trofymchuk, Serhii
, p. 12181 - 12198 (2021/09/13)
A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
Copper-Mediated Aromatic 1,1-Difluoroethylation with (1,1-Difluoroethyl)trimethylsilane (TMSCF2CH3)
Li, Xinjin,Zhao, Jingwei,Wang, Yunze,Rong, Jian,Hu, Mingyou,Chen, Dingben,Xiao, Pan,Ni, Chuanfa,Wang, Limin,Hu, Jinbo
, p. 1789 - 1792 (2016/07/07)
A new method for the formation of 1,1-difluoroethyl copper species (“CuCF2CH3”) with 1,1-difluoroethylsilane (TMSCF2CH3) has been developed. The “CuCF2CH3” species can be applied to the efficient 1,1-difluoroethylation of diaryliodonium salts under mild conditions, affording (1,1-difluoroethyl)arenes in good to excellent yields. This convenient procedure tolerates a wide range of functional groups and thus serves as a practical synthetic tool for the introduction of CF2CH3 group(s) into complex molecules.
METHOD FOR PRODUCING 1,1-DIFLUOROALKYL-AROMATIC COMPOUND
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Paragraph 0028, (2020/10/19)
PROBLEM TO BE SOLVED: To provide a method for producing a 1,1-difluoroalkyl-aromatic compound, using an economical fluorinating agent which, when being handled, does not require any particular attention nor any special reactor. SOLUTION: Provided is an economical and safe method for producing a 1,1-difluoroalkyl-aromatic compound represented by formula (III) by reacting a [difluoro(trimethylsilyl)methyl]-aromatic compound represented by formula (I) (R1 represents a halogen group or a trimethylsilyl group) with a halogenated alkyl represented by formula (II) (R2 represents a C1-3 alkyl; and X represents a halogen group) in the presence of potassium fluoride. COPYRIGHT: (C)2015,JPOandINPIT