1001180-04-6

Basic information

• Product Name: Boc-(S)-3-aMino-2-(4-chlorophenyl)propanoic acid
• Synonyms: Boc-(S)-3-aMino-2-(4-chlorophenyl)propanoic acid;(S)-3-tert-Butoxycarbonylamino-2-(4-chloro-phenyl)-propionic acid;(S)-3-((TERT-BUTOXYCARBONYL)AMINO)-2-(4-CHLOROPHENYL)PROPANOIC ACID
• CAS NO: 1001180-04-6
• Molecular Formula: C₁₄H₁₈ClNO₄
• Molecular Weight: 299.75002
• EINECS: -0
• Mol File: 1001180-04-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Boc-(S)-3-aMino-2-(4-chlorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(S)-3-aMino-2-(4-chlorophenyl)propanoic acid(1001180-04-6)
• EPA Substance Registry System: Boc-(S)-3-aMino-2-(4-chlorophenyl)propanoic acid(1001180-04-6)

Safety Data

• Hazardous Substances Data: 1001180-04-6(Hazardous Substances Data)

Upstream product

• 1001179-98-1 tert-butyl 2,4-dimethoxybenzyl((S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl)carbamate 
• 1001179-95-8 tert-butyl 2,4-dimethoxybenzyl(methoxymethyl)carbamate 
• 1001181-01-6 tert-butyl 2,4-dimethoxybenzylcarbamate 
• 1001180-07-9 (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1001180-01-3 tert-butyl (S)-(3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl)carbamate 

Downstream Products

• 1001180-07-9 (S)-3-amino-2-(4-chlorophenyl)propanoic acid hydrochloride 

Relevant articles and documents

Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors

The discovery and optimization of a series of 6,7-dihydro-5H-cyclopenta[d] pyrimidine compounds that are ATP-competitive, selective inhibitors of protein kinase B/Akt is reported. The initial design and optimization was guided by the use of X-ray structures of inhibitors in complex with Akt1 and the closely related protein kinase A. The resulting compounds demonstrate potent inhibition of all three Akt isoforms in biochemical assays and poor inhibition of other members of the cAMP-dependent protein kinase/protein kinase G/protein kinase C extended family and block the phosphorylation of multiple downstream targets of Akt in human cancer cell lines. Biological studies with one such compound, 28 (GDC-0068), demonstrate good oral exposure resulting in dose-dependent pharmacodynamic effects on downstream biomarkers and a robust antitumor response in xenograft models in which the phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway is activated. 28 is currently being evaluated in human clinical trials for the treatment of cancer.

HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.