1001185-45-0Relevant articles and documents
Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists
O'Brien-Brown, James,Jackson, Alexander,Reekie, Tristan A.,Barron, Melissa L.,Werry, Eryn L.,Schiavini, Paolo,McDonnell, Michelle,Munoz, Lenka,Wilkinson, Shane,Noll, Benjamin,Wang, Shudong,Kassiou, Michael
, p. 433 - 439 (2017)
Here we report adamantyl cyanoguanidine compounds based on hybrids of the adamantyl amide scaffold reported by AstraZeneca and cyanoguanidine scaffold reported by Abbott Laboratories. Compound 27 displayed five-fold greater inhibitory potency than the lea
KINASE INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
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Page/Page column 10, (2009/03/07)
Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use