1001354-51-3

Basic information

• Product Name: H-cis-4-Fluoro-Pro-OH.HCl
• Synonyms: H-cis-4-Fluoro-Pro-OH.HCl;(2S,4S)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride;((2S,4S)-4-Fluoropyrrolidin-2-yl)methanol hydrochloride
• CAS NO: 1001354-51-3
• Molecular Formula: C₅H₈FNO₂*ClH
• Molecular Weight: 169.58
• Mol File: 1001354-51-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-cis-4-Fluoro-Pro-OH.HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-cis-4-Fluoro-Pro-OH.HCl(1001354-51-3)
• EPA Substance Registry System: H-cis-4-Fluoro-Pro-OH.HCl(1001354-51-3)

Safety Data

• Hazardous Substances Data: 1001354-51-3(Hazardous Substances Data)

Usage

General Description

H-cis-4-Fluoro-Pro-OH.HCl is a chemical compound with the molecular formula C3H6FNO2?HCl. It is a hydrochloride salt of the organic compound H-cis-4-Fluoro-Pro-OH, which is likely a derivative of the amino acid proline. The compound contains a fluorine substituent attached to the fourth carbon of the proline ring. It is likely used in pharmaceutical research and drug development, possibly as a potential therapeutic agent or as a precursor to other biologically active molecules. The hydrochloride salt form is commonly used to increase the solubility and stability of the compound for various applications. Further specific details on the exact properties, uses, and potential hazards of H-cis-4-Fluoro-Pro-OH.HCl would require additional information.

Upstream product

• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 203866-16-4 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 

Downstream Products

• 79108-50-2 1-Nitroso-cis-4-fluoro-L-proline 

Relevant articles and documents

Synthesis and antibacterial activity of 6(R)- and 6(S)-fluoropenibruguieramine As: Fluorine as a probe for testing the powerfulness of memory of chirality (MOC)

The synthesis of 6(R)- and 6(S)- fluoropenibruguieramine As has been achieved, employing the elegant strategy developed by Kim and co-workers. Single diastereomers were formed via the key intramolecular aldol reaction, and both of the products were unambiguously confirmed by X-ray diffraction crystallography. This reaction shows that the fluorine amide effect could not compete with the memory of chirality (MOC) effect, thus further demonstrating the powerfulness of MOC effect in asymmetric synthesis. The biological testing carried out in this work indicates that the principal of antibacterial activity of the natural extract is probably not penibruguieramine A.

Automated Radiosynthesis of cis- And trans-4-[18F]Fluoro- l -proline Using [18F]Fluoride

The positron emission tomography imaging agents cis- and trans-4-[18F]fluoro-l-proline are used for the detection of numerous diseases such as pulmonary fibrosis and various carcinomas. These imaging agents are typically prepared by nucleophilic fluorination of 4-hydroxy-l-proline derivatives, with [18F]fluoride, followed by deprotection. Although effective radiofluorination reactions have been developed, the overall radiosynthesis process is suboptimal due to deprotection methods that are performed manually, require multiple steps, or involve harsh conditions. Here we describe the development of two synthetic routes that allow access to precursors, which undergo highly selective radiofluorination reactions and rapid deprotection, under mild acidic conditions. These methods were found to be compatible with automation, avoiding manual handling of radioactive intermediates.